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Use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin, oxytocin and DDAVP in rats after prolonged infusion of DDAVP

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Summary

Specific radioimmunoassays (RIA) were employed for measuring plasma and neurohypophysial concentrations of oxytocin (OT) and vasopressin (AVP) after administration of 1-deamino-8-D-Arg-vasopressin (DDAVP). DDAVP concentrations were measured by a newly-developed specific RIA. Through the use of minipumps, DDAVP was infused i.p. over a period of 3 days in normally hydrated rats. Despite decreased urine production and increased urine osmolality no changes could be observed in neurohypophysial and plasma hormone concentrations.

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Authors and Affiliations

  1. Institute of Zoophysiology, University of Lund, S-22362, Lund, Sweden

    S. Lundin, P. Melin & H. Vilhardt

  2. Ferring Pharmaceuticals, Box 30561, S-20062, Malmö, Sweden

    S. Lundin, P. Melin & H. Vilhardt

  3. Department of Medical Physiology C, University of Copenhagen, DK-2200 N, Copenhagen, Denmark

    S. Lundin, P. Melin & H. Vilhardt

Authors
  1. S. Lundin
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  2. P. Melin
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  3. H. Vilhardt
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Lundin, S., Melin, P. & Vilhardt, H. Use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin, oxytocin and DDAVP in rats after prolonged infusion of DDAVP. Experientia 41, 933–935 (1985). https://doi.org/10.1007/BF01970020

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  • DOI: https://doi.org/10.1007/BF01970020

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