Summary
Gene therapy provides new options for medicine, and implies new responsibilities for making decisions relating to the limitations which reason and morality impose upon manipulation of the human genome for the benefit both of patients and of society. This contribution outlines the possibilities and limits of gene therapy in man from a medico-technical viewpoint.
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References
Anderson, W. F., Prospects of human gene therapy. Science226 (1984) 401–409.
Baudet, A. I., Bibliography of cloned human DNA's. Am. J. hum. Genet.37 (1985) 386–406.
Bilheimer, D. W., Goldstein, J. L., Grundy, S. C., Starzl, T. E., and Brown, M. S., Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N. Engl. J. Med.311 (1984) 1658–1664.
Cline, M. J., Stang, H., Mercola, K., Morse, L., Ruprecht, R., Browne, J., and Salser, W., Gene transfer in intact animals. Nature284 (1980) 422–425.
Constantini, F., and Jaenisch, R., (Eds) Genetic manipulation of the early mammalian embryo. Banbury report No. 20, Cold Spring Harbor Laboratory 1985.
Dick, J. E., Magli, M. C., Phillips, R. A., and Bernstein, A., Genetic manipulation of hematopoietic stem cells. Trends in Genetics2 (1986) 165–170.
Donnall, Th. E., Marrow transplantation for nonmalignant disorders. N. Engl. J. Med.312 (1985) 46–47.
Krivit, W., Piermont, M. E., Ayaz, K., Tsai, M., Ramsay, N. K. C., Kersey, J. H., Weisdorf, S., Sibley, R., Snover, D., McGovern, M. M., Schwartz, M. F., and Desnick, R. J., Bone marrow transplantation in the Maroteaux-Lamy-syndrome (Mucopolysaccharidosis Type VI). N. Engl. J. Med.311 (1984) 1606–1611.
Müller, Hj., Human in vitro fertilization and embryo transfer: expectations and concerns. Experientia41 (1985) 1515–1517.
Müller, Hj., Gentherapie beim Menschen, eine Standortanalyse. Veröffentlichung des Schweiz. Institutes für Rechtsvergleich, Vol. 4. Lausanne 1986.
Mulligan, R. C., and Berg, P., Experession of a bacterial gene in mammalian cells. Science209 (1980) 1422–1427.
Neumann, E., Schaefer-Ridder, M., Wang, Y., and Hofschneider, P. H., Gene transfer into mouse L-cells by electroporation in high electric fields. EMBO J.1 (1982) 841–845.
Palmiter, R. D., and Brinster, R. L., Transgenic mice. Cell41 (1985) 343–345.
Parkman, R., The application of bone marrow transplantation to the treatment of genetic diseases. Science232 (1986) 1374–1378.
Pellicer, A., Wigler, M., Axel, R., and Silverstein, S., The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell14 (1979) 133–141.
Proceedings of the III. World Congress of in vitro Fertilization and Embryo Transfer, Helsinki, Finland (1984).
Schaffner, W., Direct transfer of cloned genes from bacteria to mammalian cells. Proc. natn. Acad. Sci. USA (1980) 2163–2167.
Shapiro, L. J., Treatment of genetic diseases, in: Principles and Practice of Medical Genetics, pp. 1488–1496. Eds A. E. H. Emery and D. Rimoin. Churchill Livingstone, Edinburgh and London 1983.
Spradling, A. C., and Rubin, G. M., The effecxt of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene. Cell34 (1983) 47–57.
Williams, D. A., Orkin, S. H., and Mulligan, R. C., Retrovirus-mediated transfer of human adenosine deaminase sequences into cells in culture into murine hematopoietic cell vivo. Proc. natn. Acad. Sci. USA83 (1986) 2566–2570.
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Müller, H. Human gene therapy: possibilities and limitations. Experientia 43, 375–378 (1987). https://doi.org/10.1007/BF01940416
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DOI: https://doi.org/10.1007/BF01940416