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Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes

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Summary

The specific thiol protease inhibitor, NCO-700, which is related to L-trans-epoxysuccinylpeptides, inhibited oxidant production by chemoattractant-stimulated rabbit polymorphonuclear leukocytes. NCO-700 could also scavenge active oxygen generated from sodium hypochlorite-hydrogen peroxide and hypoxanthine-xanthine oxidase systems.

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Authors and Affiliations

  1. Department of Pharmacology, Akita University School of Medicine, 010, Akita, Japan

    K. Tawara, S. Fujisawa & K. Nakai

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  1. K. Tawara
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  2. S. Fujisawa
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  3. K. Nakai
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Tawara, K., Fujisawa, S. & Nakai, K. Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes. Experientia 44, 346–347 (1988). https://doi.org/10.1007/BF01961277

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  • DOI: https://doi.org/10.1007/BF01961277

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