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Interaction of salicylate and noise results in mortality of rats

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Survival as a function of salicylate dose and the intensity of environmental noise was investigated in 150 adult female pigmented rats. Rats were assigned to groups (n=6/group) defined by combinations of salicylate levels from 0- (saline) to 300 mg/kg, injected subcutaneously, and noise levels from ambient noise to 98 dB SPL, presented daily for 10-h periods for up to 17 days. Mortality occurred in groups exposed to the higher combinations of salicylate and noise.

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Authors and Affiliations

  1. University of Massachusetts at Boston, Boston, (USA)

    J. F. Brennan

  2. Department of Surgery, Section of Otolaryngology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, Connecticut, USA

    P. J. Jastreboff

Authors
  1. J. F. Brennan
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  2. P. J. Jastreboff
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Brennan, J.F., Jastreboff, P.J. Interaction of salicylate and noise results in mortality of rats. Experientia 45, 731–734 (1989). https://doi.org/10.1007/BF01974571

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  • DOI: https://doi.org/10.1007/BF01974571

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