Summary
The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n=11) or a regular-sodium diet (n=10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels.
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Lattion, A.L., Flückiger, J.P., Waeber, B. et al. Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension. Experientia 46, 69–72 (1990). https://doi.org/10.1007/BF01955419
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DOI: https://doi.org/10.1007/BF01955419