Skip to main content
Log in

The role of beta-receptor and calcium-entry-blocking agents in acute myocardial infarction in the thrombolytic ear: Can the results of thrombolytic reperfusion be enhanced?

  • Focused Section on Reperfusion
  • Editorial Comment
  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Yusuf S. Interventions that potentially limit infarct size: Overview of clinical trials. Am J Cardiol 1987;60:11A-17A.

    Google Scholar 

  2. De Wood MA, Spores J, Notske R, et al. Prevalence of total coronary occlusion during the early hours of acute transmural myocardial infarction. N Engl J Med 1980;303:897–902.

    Google Scholar 

  3. Fitzgerald JD. By what means might beta blockers prolong life after acute myocaridal infarction. Eur Heart J 1987; 8:945–951.

    Google Scholar 

  4. ISIS-1 (First International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. Lancet 1986;2:57–66.

    Google Scholar 

  5. Sleight P for the ISIS-1 Trial Group. Beta blockade early in acute myocardial infarction. Am J Cardiol 1987;60:6A-10A.

    Google Scholar 

  6. Muller J, Morrison J, Stone PH, et al. Nifedipine therapy for patients with threatened and acute myocardial infrarction: A randomized double-blind placebo-controlled comparison. Circulation 1984;69:740–747.

    Google Scholar 

  7. Sirnes PA, Overskeid K, Pederson TR, et al. Evolution of infarct size during the early use of nifedipine in patients with acute myocardial infarction. The Norweigian Nifedipine Multicenter Trial. Circulation 1984;70:638–644.

    Google Scholar 

  8. Gottlieb SI, Weiss JL, Flsherty JT, et al. Effect of nifedipine on clinical course and left ventricular function in low risk acute myocardial infarction: A double-blind randomized trial. Circulation 1984;70:11–257.

    Google Scholar 

  9. Wilcox RG, Hampton JR, Banks DC, et al. Trial of early nifedipine in acute myocardial infarctions: The Trent Study. Br Med J 1986;243:1204–1208.

    Google Scholar 

  10. Branagan JP, Walsh K, Kelly P, et al. Effect of early treatment with nifedipine in suspected acute myocardial infarction. Eur Heart J 1986;7:858–865.

    Google Scholar 

  11. Walker LJE, MacKenzie G, Adgey AAJ. Effect of nifedipine on enzymatically estimated infarct size in the early phase of acute myocardial infarction. Br Heart J 1988;59:403–410.

    Google Scholar 

  12. Gottlieb SO, Becker LC, Weiss JL, et al. Nifedipine in acute myocardial infarction: An assessment of left ventricular function, infarct size, and infarct expansion. A double blind, randomized, placebo controlled trial. Br Heart J 1988; 59:411–418.

    Google Scholar 

  13. Danish Multicenter Study Group on Verapamil in Myocardial Infarction. Verapamil in acute myocardial infarction. Am J Cardiol 1984;54:24E-28E.

    Google Scholar 

  14. Bussmann WD, Seher W, Gruengras M. Reduction of creatinine and kinase and creatine kinase-MB indexes of infarct sizeby intravenous verapamil. Am J Cardiol 1984;54:1224–1230.

    Google Scholar 

  15. Crea F, Deanfield J, Crean P, et al. Effects of verapamil in preventing postinfarction angina and reinfarction. Am J Cardiol 1985;55:900–904.

    Google Scholar 

  16. Gibson RS, Boden WE, Theroux P, et al. Diltiazem and reinfarction in patients with non-Q-wave myocardial infarction. N Engl J Med 1986;315:423–429.

    Google Scholar 

  17. Hearse DJ, Yellon DM, Downey JM. Can beta blockers limit myocardial infarct size? Eur Heart J 1986;7:925–930.

    Google Scholar 

  18. Becker LC, Ambrosio G. Myocardial consequences of reper-fusion. Prog Cardiovasc Dis 1987;30(1):23–44.

    Google Scholar 

  19. Lucchesi BR. Role of neutrophils in ischemic heart disease: Pathophysiologic role in myocardial ischemia and coronary artery reperfusion. In: Mehta JL, ed. Thrombosis and Platelets in Myocardial Ischemia, Cardiovascular Clinics. Philadelphia: FA Davis, 1987;35–48.

    Google Scholar 

  20. Kloner RA, Braunwald E. Effects of calcium antagonists on infarcting myocardium. Am J Cardiol 1987;59:84B-94B.

    Google Scholar 

  21. Jennings RB, Reimer KA. Factors involved in salvaging ischemic myocardium: Effect of reperfusion of arterial blood. Circulation 1983;68(suppl 1):I-25-I-36.

    Google Scholar 

  22. Nayler WG. Calcium antagonists and the ischemic myocardium. Int J Cardiol 1987;15:267–285.

    Google Scholar 

  23. Murphy JG, Marsh JD, Smith TW. The role of calcium in ischemie injury. Circulation 1987;75(suppl V):V-15.

    Google Scholar 

  24. Murphy JG, Smith TW, Marsh JD. Mechanism of reoxygenation-induced ealcium overload in cultured chick embryo ventricular cells. Am J Physiol (in press).

  25. Przyklenk K, Kloner RA. Superoxide dismutase plus catalase improve contractile function in the canine model of the “stunned myocardium”. Circ Res 1986;58:148–156.

    Google Scholar 

  26. Hammerman H, Kloner RA, Briggs LL, Braunwaid E. Enhancement of salvage of reperfused myocardium by early beta-adrenergic blockade (timolol). J Am Coll Cardiol 1984;3:1438–1443.

    Google Scholar 

  27. Van De Werf F, Vanhaeche J, Jany I-K, et al. Reduction in infarct size and enhanced recovery of systolic function after coronary thrombolysis with tissue-type plasminogen activator combined with β-adrenergic blockade with metoprolol. Circulation 1987;75:830–836.

    Google Scholar 

  28. Bush LR, Buja LM, Tilton G, et al. Effects of propranolol and diltiazem alone and in combination on the recovery of left ventricular segmental function after long-term reperfusion following temporary coronary occlusion in conscious dogs. Circulation 1985;72:413–430.

    Google Scholar 

  29. White HD, Norris RM, Brown MA, et al. Effect of intravenous streptokinase on left ventricular function and early survival after acute myocardial infarction. N Engl J Med 1987;317:850–855.

    Google Scholar 

  30. Knabb RM, Rosamond TL, Rox KA, et al. Enhancement of salvage of reperfused ischemic myocardium by diltiazem. J Am Coll Cardiol 1986;8:861–871.

    Google Scholar 

  31. Erbel R, Pop T, Meinertz T, et al. Combination of calcium channel blocker and thrombolytic therapy in acute myocardial infarction. Am Heart J 1988;115:529–538.

    Google Scholar 

  32. Przyklenk K, Kloner RA. Nifedipine administration postreperfusion ablates the phenomenon of the “stunned myocardium” (abstr). Circulation 1987;76(Suppl IV):IV-198.

    Google Scholar 

  33. Przyklenk K, Kloner RA. Effect of verapamil on postischemic “stunned” myocardium: Importance of timing of treatment. J Am Coll Cardiol 1988;11:614–623.

    Google Scholar 

  34. Ito BR, Tate H, Kobayashi M, Schaper W. Reversibly injured, postischemic canine myocardium retains normal contractile reserve. Circ Res 1987;61:834–846.

    Google Scholar 

  35. HINT Research Group (Holland Interuniversity Nifedipine/Metoprolol Trial); Early treatment of unstable angina in the coronary care unit: A randomised double-blind placebo-controlled comparison of recurrent ischaemia in patients treated with nifedipine or metoprolol or both. Br Heart J 1986;56:400–413.

    Google Scholar 

  36. Opie LH: Calcium channel antagonists. Part II: Use and comparative properties of the three prototypical calcium antagonists in ischemic heart disease, including recommendations based on an analysis of 41 trials. Cardiovasc Drugs Ther 1988;1:461–491.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lavie, C.J., Murphy, J.G. & Gersh, B.J. The role of beta-receptor and calcium-entry-blocking agents in acute myocardial infarction in the thrombolytic ear: Can the results of thrombolytic reperfusion be enhanced?. Cardiovasc Drug Ther 2, 601–607 (1988). https://doi.org/10.1007/BF00054199

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00054199

Key words

Navigation