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Study of haemodialysis materials; physico-chemical and biological characterization of EVALVA, EVAPA and heparinized EVAPA

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Abstract

Partially hydrolyzed ethylene/vinyl acetate copolymers were modified by the covalent binding of a heparin-complexing polymer and further heparinized in order to improve their blood compatibility. These heparinizable polymeric materials (EVAPA) were obtained by a two-step reaction between an ethylene/vinyl alcohol/vinyl acetate (EVALVA) terpolymer, and the heparin complexing polymer N2LL. The physico-chemical characterization of EVALVA, EVAPA and heparinized-EVAPA was carried out through thermal analysis, SEM, contact angle, potentiometric measurements, water uptake and FT-IR spectroscopic measurements. The biocompatibility of the above-mentioned samples was evaluated usingin vitro methods, through the determination of heparin release in phosphate buffer solution (PBS) and in human plasma, and with the investigation of hemostasis activation.

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Authors and Affiliations

  1. C.R.I.S.M.A., Università di Siena, Via Ettore Bastianini, 12 53100, Siena, Italy

    R. Barbucci, A. Albanese & F. Tempesti

  2. Universitè Paris Sud Physico-Chimie des Surfaces Centre d'Etudes Pharmaceutiques, Rue J. B. Clèment 92296, Chatenay Malabry Cedex, France

    A. Baszkin

  3. BOMATECH Zone Industrielle del'lslon, Rue Pasteur-38670, Chasse sur Rhone, France

    R. Eloy

  4. Istituto di Ricerca e Tecnologia delle Materie Plastiche C.N.R., Via Toiano 6, 80072 Arco Felice, Napoli, Italy

    E. Martuscelli & S. Cimmino

Authors
  1. R. Barbucci
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  2. A. Albanese
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  3. F. Tempesti
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  4. A. Baszkin
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  5. R. Eloy
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  6. N. Weill
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  7. E. Martuscelli
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  8. S. Cimmino
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Barbucci, R., Albanese, A., Tempesti, F. et al. Study of haemodialysis materials; physico-chemical and biological characterization of EVALVA, EVAPA and heparinized EVAPA. J Mater Sci: Mater Med 5, 844–849 (1994). https://doi.org/10.1007/BF01172022

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  • DOI: https://doi.org/10.1007/BF01172022

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