Skip to main content
Log in

Diffusion of Steroids in Porous Sol-Gel Glass: Application in Slow Drug Delivery

  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

Samples of porous sol-gel glass, after being stabilized at 750°C, were impregnated with progesterone, estradiol, estrone, and hydrocortisone. Diffusion coefficients for those steroids inside the pores filled with pure ethanol, ethanol-water mixture or physiological solution were determined. It is shown that permeability is favored for steroids having fewer hydroxyl and carbonyl groups. Solvents that readily dissolve steroids increase the diffusion rate and thus the amount of delivered material. The flow of steroids in small pores is less restricted than in larger pores.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. C.J. Brinker and G.W. Scherer, Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing (Academic Press, San Diego, 1990).

    Google Scholar 

  2. N. Koone and T.W. Zerda, J. Sol-Gel Sci. Tech. (submitted).

  3. T.W. Zerda, A. Brodka, and J. Coffer, J. Non-Cryst. Solids 168, 33 (1994).

    Google Scholar 

  4. Y. Shao and T.W. Zerda, Chem. Phys. Lett. 209, 247 (1993).

    Google Scholar 

  5. L. Nikiel and T.W. Zerda, J. Phys. Chem. 95, 4063 (1991).

    Google Scholar 

  6. J. Watson and T.W. Zerda, Appl. Spectrosc. 45, 1360 (1991).

    Google Scholar 

  7. N. Koone and T.W. Zerda, J. Non-Cryst. Solids 183, 243 (1995).

    Google Scholar 

  8. L.L. Hench and M. Wilson, J. Non-Cryst. Solids 121, 234 (1990).

    Google Scholar 

  9. C.L. Prosser, Comparative Animal Physiology (W.B. Saunders Co., Philadelphia, 1950), p. 95.

    Google Scholar 

  10. J. Crank, The Mathematics of Diffusion (Oxford University Press, Oxford, 1975), chap. 5.

    Google Scholar 

  11. D.W. Sindorf and G.E. Maciel, J. Phys. Chem. 87, 5516 (1983).

    Google Scholar 

  12. J. Mazan, B. Leclerc, H. Porte, G. Torres, and G. Couarraze, J. Mat. Sci., Mat. Med. 4, 175 (1993).

    Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sieminska, L., Ferguson, M., Zerda, T. et al. Diffusion of Steroids in Porous Sol-Gel Glass: Application in Slow Drug Delivery. Journal of Sol-Gel Science and Technology 8, 1105–1109 (1997). https://doi.org/10.1023/A:1018383702399

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018383702399

Navigation