Summary
Specific neurotoxic destraction of the serotoninergic innervation of the subcommissural organ of the rat is followed by an efficient reinnervation by collateral sprouting of non-monoaminergic axons, which normally do not innervate the SCO cells. Morphologically, the reinnervating fibres totally replace the serotoninergic synapses lost by the lesion, but, functionally, they fail to substitute for the potent inhibitory control of secretory activity normally exerted by the serotoninergic innervation. It is possible that the observed reinnervation by foreign synapses explains why the regrowing serotoninergic neurons fail to re-establish their connections with the SCO.
Similar content being viewed by others
References
Baumgarten, H. G., Lachenmayer, L. andBjörklund, A. (1977) Chemical lesioning of indoleamine pathways. InMethods in Psychobiology (edited byMyers, R. D.), pp. 47–98. New York: Academic Press.
Baumgarten, H. G., Lachenmayer, L., Björklund, A., Nobin, A. andRosengren, E. (1973) Long-term recovery of serotonin concentrations in the rat CNS following 5,6-dihydroxytryptamine.Life Sciences 12, 357–64.
Björklund, A., Katzman, R., Stenevi, U. andWest, K. A. (1971) Development and growth of axonal sprouts from noradrenaline and 5-hydroxytryptamine neurons in the rat spinal cord.Brain Research 31, 21–33.
björklund, A. andLindvall, O. (1979) Reformation of normal terminal innervation patterns by central noradrenergic neurons after 5,7-dihydroxytryptamine-induced axotomy.Brain Research (in press).
Björklund, A., Nobin, A. andStenevi, U. (1973) Regeneration of central serotonin neurons after axonal degeneration induced by 5,6-dihydroxytryptamine.Brain Research 50, 214–20.
Björklund, A., andStenevi, U. (1971) Growth of central catecholamine neurons into smooth muscle grafts in the rat mesencephalon.Brain Research 31, 1–20.
Björklund, A., Stenevi, U. andSvendgaard, N. Aa. (1976) Growth of transplanted monoaminergic neurons into the adult hippocampus along the perforant path.Nature 262, 787–90.
Clemente, C. D. (1964) Regeneration in the vertebrate central nervous system.International Review of Neurobiology 6, 257–301.
Cotman, C. W. andLynch, G. S. (1976) Reactive synaptogenesis in the adult nervous system: the consequences of partial deafferentiation on new synapse formation. InNeuronal Recognition (edited byBarondes, S. H.), pp. 69–108. New York: Plenum Press.
Goodman, D. C., Bogdasarian, R. S. andHorel, J. A. (1973) Axonal sprouting of ipsilateral optic tract following opposite eye removal.Brain, Behavior and Evolution 8, 27–50.
Katzman, R., Björklund, A., Owman, Ch., Stenevi, U. andWest, K. A. (1971) Evidence for regenerative axon sprouting of central catecholamine neurons in the rat mesencephalon following electrolytic lesions.Brain Research 25, 579–96.
Kimble, J. E. andMøllgård, K. (1975) Subcommissural organ-associated neurons in fetal and neonatal rabbit.Cell and Tissue Research 159, 195–204.
Liu, C.-N. andChambers, W. W. (1958) Intraspinal sprouting of dorsal root axons.Archives of Neurology and Psychiatry 79, 46–61.
Lund, R. D. andLund, J. S. (1971) Synaptic adjustment after deafferentation of the superior colliculus of the rat.Science 171, 804–7.
Møllgård, K., Lundberg, J. J., Wiklund, L., Lachenmayer, L. andBaumgarten, H. G. (1978) Morphological consequences of serotonin neurotoxin administration: neuron-target cell interaction in the rat subcommissural organ.Annals of the New York Academy of Sciences 305, 262–88.
Møllgård, K. andWiklund, L. (1979) Serotoninergic synapses on ependymal and hypen-dymal cells of the rat subcommissural organ.Journal of Neurocytology 8, 445–67.
Moore, R. Y., Björklund, A. andStenevi, U. (1971) Plastic changes in the adrenergic innervation of the rat septal area in response to denervation.Brain Research 33, 12–35.
Murakami, F., Fujito, Y. andTsukuhara, N. (1976) Physiological properties of the newly formed corticorubral synapses of red nucleus neurons due to collateral sprouting.Brain Research 103, 147–51.
Nakamura, Y., Mizuno, N., Konishi, A. andSato, M. (1974) Synaptic reorganization of the red nucleus after chronic deafferentation from cerebellorubral fibers: an electron microscopic study in the cat.Brain Research 82, 298–301.
Nobin, A., Baumgarten, H. G., Björklund, A., Lachenmayer, L. andStenevi, U. (1973) Axonal degeneration and regeneration of the bulbospinal indolamine neurons after 5,6-dihydroxytryptamine treatment.Brain Research 56, 1–24.
Nojyo, Y. andSano, Y. (1978) Ultrastructure of the serotoninergic nerve terminals in the suprachiasmatic and interpeduncular nuclei of rat brains.Brain Research 149, 482–8.
Nygren, L.-G., Fuxe, K., Jonsson, G. andOlson, L. (1974) Functional regeneration of 5-hydroxytryptamine nerve terminals in the rat spinal cord following 5,6-dihydroxytryptamine induced degeneration.Brain Research 78, 377–94.
Nygren, L.-G. andOlson, L. (1977) Intracisternal neurotoxins and monoamine neurons innervating the spinal cord: acute and chronic effects on cell and axon counts and nerve terminal densities.Histochemistry 52, 281–306.
Östberg, A.-J. C., Raisman, G., Field, P. M., Iversen, L. L. andZigmond, R. E. (1976) A quantitative comparison of the formation of synapses in the rat superior cervical ganglion by its own and by foreign nerve fibers.Brain Research 107, 445–70.
Raisman, G. (1969) Neuronal plasticity in the septal nuclei of the adult rat.Brain Research 14, 25–48.
Raisman, G. andField, P. M. (1973) A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei.Brain Research 50, 241–64.
Stenevi, U., Björklund, A. andMoore, R. Y. (1972) Growth of intact central adrenergic axons in the denervated lateral geniculate body.Experimental Neurology 35, 290–9.
Svendgaard, N. A., Björklund, A. andStenevi, U. (1975) Regenerative properties of central monoamine neurons. Studies in the adult rat using cerebral iris implants as targets.Advances in Anatomy, Embryology and Cell Biology 51, 1–76.
Tsukuhara, N., Hultborn, H., Murakami, F. andFujito, Y. (1975) Electro-physiological study of formation of new synapses and collateral sprouting in red nucleus neurons after partial denervation.Journal of Neurophysiology 38, 1359–72.
Wiklund, L., Björklund, A. andNobin, A. (1978) Regeneration of serotonin neurons in the rat brain after 5,6-DHT induced axotomy.Annals of the New York Academy of Sciences 305, 370–84.
Windle, W. F. (editor) (1955)Regeneration in the Central Nervous System. Springfield: Thomas.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wiklund, L., Møllgård, K. Neurotoxic destruction of the serotoninergic innervation of the rat subcommissural organ is followed by reinnervation through collateral sprouting of non-monoaminergic neurons. J Neurocytol 8, 469–480 (1979). https://doi.org/10.1007/BF01214803
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01214803