Skip to main content
SpringerLink
Log in

Edelfosine, apoptosis, MDR and Na+/H+ exchanger: Induction mechanisms and treatment implications

  • Published:
Apoptosis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Mollinedo F, Fernández Luna JL, Gajate C, et al. Selective induction of apoptosis in cancer cells by the ether ET-18–OCH3 (edelfosine): molecular structure requirements, cellular uptake, and protection by bcl-2 and bcl xL. Cancer Res 1997; 57: 1320–1328.

    Google Scholar 

  2. Shemtov MM, Cheng DL-W, Kong L, et al. LAK cell mediated apoptosis of human bladder cancer cells involves a pH-dependent endonuclease system in the cancer cell: possible mechanism of BCG therapy. J Urology 1995; 154: 269–274.

    Google Scholar 

  3. Rebollo A, Gómez J, de Aragón AM, Lastres P, Silva A, Pérez-Sala D. Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidification. Exp Cell Res 1995; 218: 581–585.

    Google Scholar 

  4. Pérez-Sala D, Collado-Escobar D, Mollinedo F. Intracellular alkalinization supresses lovastatin-induced apoptosis in HL60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 1995; 270: 6235–6242.

    Google Scholar 

  5. Li J, Eastman A. Apoptosis in an interleukin-2–dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na+/H+-Antiport. J Biol Chem 1995; 270: 3203–3211.

    Google Scholar 

  6. Reynolds JE, Li JF, Craig RW, Eastman, A. BCL-2 and MCL-1 expression in chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp Cell Res 1996; 225: 430–436.

    Google Scholar 

  7. Wolf CM, Reynolds JE, Morana SJ, Eastman, A. The temporal relationship between protein phosphatase. ICE/CED-3 proteases, intracellular acidification, and DNA fragmentation in apoptosis. Exp Cell Res 1997; 230(1): 22–27.

    Google Scholar 

  8. Angoli D, Delia D, Wank E. Early cytoplasmatic acidification un retinamide-mediated apoptosis of human leukemia cells. Biochem Biophys Res Com 1996; 229(2): 681–685.

    Google Scholar 

  9. Li J, Eastman A. Apoptosis in an interleukin-2–dependent cytotoxic T lympohocyte cell line is associated with intracellular acidification, Role of the Na. + //H. + /-antiport. J Biol Chem 1995; 270(2): 3203–3211.

    Google Scholar 

  10. Harguindey S, Catalán J, Antón-Aparicio LM. Possible exploitation of an H+-related mechanism in the treatment of breast and colon tumors: a new approach to the adjuvant treatment of cancer. In: Crane FL, Morré DJ, L¨ow H, eds. Plasma Oxidoreductases in Control of Animal and Plant Growth. NewYork: Plenum Press 1988: 415–418.

    Google Scholar 

  11. Maidhorn RPE, Cragoe EJ Jr, Tannock IF. Therapeutic potential of analogues of amiloride: inhibition to the regulation of intracellular pH as a possible mechanism of tumor selective therapy. Br J Cancer 1993; 67: 297–303.

    Google Scholar 

  12. Harguindey S, Pedraz JL, García Cañero R., Pérez de Diego J, Cragoe, EJ. Jr. Hydrogen ion-dependent oncogenesis and parallel new avenues to cancer prevention and treatment using aH+-mediated unifying approach: pH-related and pH-unrelated mechanisms. Critical Rev Oncogenesis 1995; 6(1): 1–33.

    Google Scholar 

  13. Harguindey, S. Use of Na+/H+ antiporter inhibitors as a novel approach to cancer treatment. In: Cragoe EJ Jr, Kleyman ThR, Simchowitz L, eds.Amiloride and its Analogs: Unique Cation Transport Inhibitors. New York: VCH Publishers Inc. 1992: 317–334.

    Google Scholar 

  14. Harguindey S, Cragoe EJ Jr. The Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism. Med Hypotheses 1992; 39: 229–237.

    Google Scholar 

  15. Keizer HG, Joenje H. Increased cytosolic pH in multidrugresistant human lung tumor cells: effect of verapamil. J Natl Cancer Inst 1989; 81: 706–709.

    Google Scholar 

  16. Simon S, Roy D, Schindler M. Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci USA 1994; 91: 1128–1132.

    Google Scholar 

  17. Hamilton G, Cosentini EP, Teleky B, et al. The multidrugresistance modifiers verapamil, cyclosporine A and tamoxifen induce an intracellular acidification in colon carcinoma cell lines in vitro. Anticancer Res 1993; 13(6A): 2059–2063.

    Google Scholar 

  18. Oberhaensli RD, Bore PG, Rampling RP, Hilton-Jones D, Hands LJ, Radda GK. Biochemical investigation of human tumors in vivo with phosphorus-31 magnetic resonance spectroscopy. Lancet 1986; 2: 8–11.

    Google Scholar 

  19. Perona R, Portillo F, Giraldez F, Serrano R. Transformation and pH homeostasis expressing a yeast H+-ATPase containing site-directed mutations. Mol Cell Biology 1990; 10(8): 4110–4115.

    Google Scholar 

  20. Besson P, Goré J, Vincent E, Hoinard C, Bougnoux, P. Inhibition of the Na+/H+ exchanger activity by an alkyllysophospholipid analogue in a human breast cancer cell line. Biochem Pharmacol 1996; 51: 1153–1158.

    Google Scholar 

  21. Weinsburg JH, Curcio M, Caron PC, et al. The multidrugresistant phenotype confers immunological resistance. J Exp Med 1996; 183(6): 2699–2704.

    Google Scholar 

  22. Stotzer OJ, Nussler V, Darsow M, et al. The role of bcl-2 and bax expression ratio for predicting response to chemotherapy in acute myleoblastic leukemia. Proc Annu Meet Am Assoc Cancer Res 1996; 37: A2169.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Clinica La Esperanza, Vitoria, Spain

    Salvador Harguindey

  2. Department of Pharmacy and Pharmaceutical Technology, University of The Basque Country (EHU), Vitoria, Spain

    Jose Luis Pedraz

  3. Laboratory of Experimental Hepatology, Department of Experimental Biochemistry, Clinica Puerta de Hierro, Madrid, Spain

    Rafael García Cañero

  4. Radiation Therapy Regional Center, Florida, 33901, USA

    Michael Katin

Authors
  1. Salvador Harguindey
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jose Luis Pedraz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rafael García Cañero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael Katin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harguindey, S., Pedraz, J.L., Cañero, R.G. et al. Edelfosine, apoptosis, MDR and Na+/H+ exchanger: Induction mechanisms and treatment implications. Apoptosis 5, 87–89 (2000). https://doi.org/10.1023/A:1009645927931

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1009645927931

Search

Navigation