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Synthesis and antiviral activity of certain aliphatic amides of N-substituted α-pyrrolidine carboxylic acids

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Pharmaceutical Chemistry Journal Aims and scope

Conclusions

  1. 1.

    A series of amides of N-substitutedα-pyrrolidine carboxylic acids are prepared for comparachemotherapeutic tests.

  2. 2.

    The antiviral activity of amides of N-substitutedα-pyrrolidine carboxylic acids are studied with respect to influenza virus type A. A connection between the chemical structure of the amides and their antiviral activity is followed in experiments in vitro and in vivo.

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Literature cited

  1. T. Ueda and S. Kato, Japanese Patent No. 2681 (1961); Ref. Zh. Khimiya, No. 7, No. 7L317 (1962).

  2. T. Ueda, S. Kato, and S. Toesima, Japanese Patent No. 7296 (1960); Ref. Zh. Khimiya, No. 2, No. 2L335 (1962).

  3. T. Ueda and S. Kato, Japanese Patent No. 2678 (1961); Ref. Zh. Khimiya, No. 7, No. 7L313 (1962).

  4. A. S. Lebedeva, A. M. Likhosherstov, and A. P. Skoldinov, Zh. Obshch. Khim.,34, 3806 (1964).

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Authors and Affiliations

  1. Scientific Research Institute of Pharmacology and Chemotherapy, Academy of Medical Sciences of the USSR, Moscow

    A. S. Lebedeva, N. S. Tolmacheva, N. A. Yushchenko, A. M. Likhosherstov & A. P. Skoldinov

Authors
  1. A. S. Lebedeva
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  2. N. S. Tolmacheva
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  3. N. A. Yushchenko
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  4. A. M. Likhosherstov
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  5. A. P. Skoldinov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 4, pp. 22–25, April, 1968.

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Lebedeva, A.S., Tolmacheva, N.S., Yushchenko, N.A. et al. Synthesis and antiviral activity of certain aliphatic amides of N-substituted α-pyrrolidine carboxylic acids. Pharm Chem J 2, 195–197 (1968). https://doi.org/10.1007/BF00759879

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  • DOI: https://doi.org/10.1007/BF00759879

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