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Antioxidant properties of certain steroids

  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    Manometric and chemiluminescent methods revealed that derivatives of D-homoestrone and D-homoestradiol possess antioxidant properties.

  2. 2.

    The greatest antioxidant effectiveness is possessed by d,l-Δ8(9)-bis-dehydro-D-homoestrone, d,l-Δ8(9),14(15)-dehydro-D-homoestradiol-3,17aβ, and d,l-Δ8(9)-bis-dehydro-D-homoestradiol-3,17aβ, for which ɛCL=9, 14, 14, and 21, respectively, in comparison with estrone.

  3. 3.

    It was shown by the method of chemilunainescence that the antioxidant activity of d,l-D-homoestradiol-3,17aβ, d,l-8-iso-D-estradiol-3,17aβ, and d,l-Δ9(11)-17a-keto-D-homoestradiol-3,14 is entirely due to their reactions with peroxide radicals of the substance to be oxidized.

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Authors and Affiliations

  1. Institute of Chemical Physics, Academy of Sciences of the USSR, USSR

    N. A. Zakharova, S. I. Sholina, K. E. Kruglyakova, O. N. Karpukhin, S. N. Ananchenko, V. E. Limanov, I. V. Torgov & N. M. Émanuél'

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  1. N. A. Zakharova
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  2. S. I. Sholina
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  3. K. E. Kruglyakova
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  4. O. N. Karpukhin
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  5. S. N. Ananchenko
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  6. V. E. Limanov
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  7. I. V. Torgov
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  8. N. M. Émanuél'
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Zakharova, N.A., Sholina, S.I., Kruglyakova, K.E. et al. Antioxidant properties of certain steroids. Russ Chem Bull 15, 429–436 (1966). https://doi.org/10.1007/BF00846099

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  • DOI: https://doi.org/10.1007/BF00846099

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