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Penicillin production: biotechnology at its best

  • Biotechnology
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Abstract

A brief description is given of the history of penicillin production in the Netherlands.

The development of today’s penicillin production technology is analysed in terms of changes in the quality and intensity of the production process. Technological as well as genetical developments are shown to be of influence on the quality and the intensity of the production process.

The analysis is illustrated by a brief description of the productivity improvement of the penicillin fermentation as it occurred at Gist-brocades during the past 20 years.

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References

  • Aberhart, D. J. 1977. Biosynthesis of β-lactam antibiotics. — Tetrahedron33: 1545–1559.

    Article  CAS  Google Scholar 

  • Abraham, E. P., Chain, E., Fletcher, C. M., Florey, H. W., Gardner, A. D., Heatley, N. G. andJennings, M. A. 1941. Further observations on penicillin. — Lancetii: 177–188.

    CAS  Google Scholar 

  • Chain, E., Florey, H. W., Gardner, A. D., Heatley, N. G., Jennings, M. A., Orr-Ewing, J. andSanders, A. G. 1940. Penicillin as a chemotherapeutic agent. — Lancetii: 226–228.

    CAS  Google Scholar 

  • Clutterbuck, P. W., Lovell, R. andRaistrick, H. 1932. Studies in the biochemistry of microorganisms. XXVI. The formation from glucose by members of thePenicillium chrysogenum series of a pigment, an alkali-soluble protein and penicillin — The antibacterial substance of Fleming. — Biochem. J.26: 1907–1918.

    CAS  Google Scholar 

  • De Flines, J. 1980. Biotechnology — Its past, present and future. p. 12–17.In A. Verbraeck (ed.), Biotechnology, a Hidden Past, a Shining Future. — TNO, The Hague.

  • Fleming, A. 1929. On the antibacterial action of cultures of aPenicillium with special reference to their use in the isolation ofB. influenzae. — Br. J. Exp. Pathol.10: 226–236.

    CAS  Google Scholar 

  • Hersbach, G. J. M. 1983. Penicillin production. — Antonie van Leeuwenhoek49: 93–94.

    Article  Google Scholar 

  • Hersbach, G. J. M., Van der Beek, C. P. andVan Dijck, P. W. M. 1984. The penicillins: properties, biosynthesis, and fermentation. p. 45–140.In E. J. Vandamme (ed.), Biotechnology of Industrial Antibiotics. Drugs and the Pharmaceutical Sciences, Vol. 22. — Marcel Dekker, Inc., New York.

    Google Scholar 

  • Heijnen, J. J., Roels, J. A. andStouthamer, A. H. 1979. Application of balancing methods in modeling the penicillin fermentation. — Biotechnol. Bioeng.21: 2175–2201.

    Article  CAS  PubMed  Google Scholar 

  • Kiese, M. 1943. Chemische Therapie mit antibakteriellen Stoffen aus niederen Pilzen und Bakterien. — Klin. Wochenschr.22: 505–511.

    Article  CAS  Google Scholar 

  • Kluyver, A. J. andPerquin, L. H. C. 1933. Zur Methodik der Schimmelstoffwechseluntersuchung. — Biochem. Z.266: 68–81.

    CAS  Google Scholar 

  • Metz, B., Kossen, N. W. F. andVan Suijdam, J. C. 1979. The rheology of mould suspensions. p. 103–156.In T. K. Ghose, A. Fiechter and N. Blakebrough (eds), Advances in Biochemical Engineering, Vol. 11. — Springer Verlag, Berlin.

    Google Scholar 

  • O’Sullivan, J. andAbraham, E. P. 1981. Biosynthesis of β-lactam antibiotics. p. 101–122.In J. W. Corcoran (ed.), Antibiotics, Vol. 4. — Springer Verlag, Berlin.

    Google Scholar 

  • Pirt, S. J. 1983. The role of microbial physiology in biotechnology. — J. Chem. Technol. Biotechnol.33B: 137–138.

    CAS  Google Scholar 

  • Queener, S. andNeuss, N. 1982. The biosynthesis of β-lactam antibiotics. p. 1–81.In R. B. Morin and M. Gorman (eds), Chemistry and Biology of β-Lactam Antibiotics, Vol. 3. — Academic Press, New York.

    Google Scholar 

  • Sylvester, J. C. andCoghill, R. D. 1954. The penicillin fermentation. p. 219–263.In L. A. Underkofler and R. J. Hickey (eds), Industrial Fermentations, Vol. 2. — Chemical Publ. Co., Inc., New York.

    Google Scholar 

  • Van der Beek, C. P., Van Dijck, P. W. M. andHersbach, G. J. M. 1984. Relationship between strain selection and penicillin productivity improvements at Gist-Brocades. p. 457–460.In E. H. Houwink and R. R. van der Meer (eds), Innovations in Biotechnology, Progress in Industrial Microbiology, Vol. 20. — Elsevier, Amsterdam.

    Google Scholar 

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Authors and Affiliations

  1. Gist-brocades N. V., Research and Development, P.O. Box 1, 2600 MA, Delft, The Netherlands

    C. P. van der Beek & J. A. Roels

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  1. C. P. van der Beek
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  2. J. A. Roels
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van der Beek, C.P., Roels, J.A. Penicillin production: biotechnology at its best. Antonie van Leeuwenhoek 50, 625–639 (1984). https://doi.org/10.1007/BF02386230

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  • DOI: https://doi.org/10.1007/BF02386230

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