Summary
Production of a lipopeptide antibiotic surfactin was carried out using a recombinantBacillus subtilis. Surfactin yield of the recombinant strain was about one and half times as much as that ofBacillus subtilis RB 14, the strain in which the surfactin gene was originated. This system is especially noteworthy because a recombinant strain surpassed the original strain in the production of a bacterial antibiotic as a secondary metabolite of the bacterium.
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Ohno, A., Ano, T. & Shoda, M. Production of a lipopeptide antibiotic surfactin with recombinantBacillus subtilis . Biotechnol Lett 14, 1165–1168 (1992). https://doi.org/10.1007/BF01027022
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DOI: https://doi.org/10.1007/BF01027022