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Adaptive control of specific growth rate based on proton production in anaerobic fed-batch culture

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Summary

This paper develops a practical and useful computer control scheme to control the specific growth rate as accurately as possible by measuring the released protons in anaerobic alcohol fermentation. In the case of current study, most of the released protons are due to the uptake of cationic ammonium ion via the conversion: NH4 + → NH3(cell) + H+. Correlating the Proton Production (PP) and the Proton Production Rate (PPR) with specific growth rate (μ) proved PP as a better measured variable. Using a simple adaptive control algorithm, μ was successfully controlled in a Zymomonas mobilis fed-batch culture.

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Authors and Affiliations

  1. Department of Chemical Technology, College of Engineering, Seoul National University, 151-742, Seoul, Korea

    J. I. Won, Y. L. Yang, B. G. Kim & C. Y. Choi

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  1. J. I. Won
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  2. Y. L. Yang
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  3. B. G. Kim
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  4. C. Y. Choi
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Won, J.I., Yang, Y.L., Kim, B.G. et al. Adaptive control of specific growth rate based on proton production in anaerobic fed-batch culture. Biotechnol Lett 15, 511–516 (1993). https://doi.org/10.1007/BF00129328

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  • DOI: https://doi.org/10.1007/BF00129328

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