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The microbial production of 3aα-H-4α- (3′-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-indan-1-one-δ-lactone from cholesterol

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Summary

A mutant strain of Rhodococcus australis CSIR-236.457 which accumulates 3aα-H-4α-(3′-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-indan-1-one-δ-lactone from cholesterol, stigmasterol and β-sitosterol was studied. The product is produced in a 60% molar yield in a dilute black strap molasses medium containing 6–12g/l cholesterol after a 72 hour fermentation period.

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Authors and Affiliations

  1. Microbiology Research Group, CSIR, P.O. Box 395, 0001, Pretoria, South Africa

    N. P. Ferreira & P. M. Robson

  2. National Chemical Research Laboratory, CSIR, P.O. Box 395, 0001, Pretoria, South Africa

    J. R. Bull

  3. National Food Research Institute, CSIR, P.O. Box 395, 0001, Pretoria, South Africa

    W. H. van der Walt

Authors
  1. N. P. Ferreira
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  2. P. M. Robson
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  3. J. R. Bull
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  4. W. H. van der Walt
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Ferreira, N.P., Robson, P.M., Bull, J.R. et al. The microbial production of 3aα-H-4α- (3′-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-indan-1-one-δ-lactone from cholesterol. Biotechnol Lett 6, 517–522 (1984). https://doi.org/10.1007/BF00139995

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  • DOI: https://doi.org/10.1007/BF00139995

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