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Violacein/β-Cyclodextrin Inclusion Complex Formation Studied by Measurements of Diffusion Coefficient and Circular Dichroism

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Abstract

The formation of inclusion compounds between violacein andβ-cyclodextrin was studied by diffusion and circulardichroism measurements. The present work was undertaken to explore the feasibilityof the β-cyclodextrin in reducing the toxicity and enhancing the antitumoral efficacy ofviolacein by forming an inclusion complex. The results of the two experimentsare in good agreement, suggesting the formation of 1 : 1 and 1 : 2 complexes.The diffusion coefficient measurements enabled estimates of the sizes of the complexesinvolved. From the circular dichroism and computational calculations it was possibleto view a preference for inclusion of the most polar part of the molecule to form a1 : 2 inclusion complex. We expect that this work proves the potential of thesetechniques to determining complex stoichiometry.

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Authors and Affiliations

  1. Biological Chemistry Laboratory, Brazil

    MariÂNgela B. M. De Azevedo & Nelson DurÁn

  2. Organic Chemistry Department, Universidad de Concepción Concepcion, Chile

    Joel B. Alderete

  3. Department of Physical Chemistry, Instituto de Química, Universidade Estadual de Campinas, C.P. 6154, CEP 13083-970, Campinas-S.P., Brazil

    Antonio C. S. Lino & Watson Loh

  4. Biochemistry Department, Universidade de São Paulo, S.P., Brazil

    Adelaide Faljoni-Alario

  5. Instituto de Química, Biological Chemistry Laboratory, Universidade Estadual de Campinas, C. P. 6154, CEP 13083-970, Campinas, Brazil

    Nelson DurÁn

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  1. MariÂNgela B. M. De Azevedo
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  2. Joel B. Alderete
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  3. Antonio C. S. Lino
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  4. Watson Loh
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  5. Adelaide Faljoni-Alario
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De Azevedo, M.B.M., Alderete, J.B., Lino, A.C.S. et al. Violacein/β-Cyclodextrin Inclusion Complex Formation Studied by Measurements of Diffusion Coefficient and Circular Dichroism. Journal of Inclusion Phenomena 37, 67–74 (2000). https://doi.org/10.1023/A:1008186706573

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  • DOI: https://doi.org/10.1023/A:1008186706573

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