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The determination of selenium in urine

  • Nuclear Analytical Methods in Biology and Medicine
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Abstract

The selenium excreted in urine can be measured to assess the dietary status of selenium, an essential trace element in human nutrition. The objectives of this work were: 1) to develop a procedure, capable of high sample throughout, by which the major interferences can be reduced such that selenium concentrations can be measured in urine by Neutron Activation Analysis (NAA) using77mSe (17.4 s; and 2) to apply the method to a human dietary selenium study in which several selenium monitors were compared. The method involves a pre-irradiation arsenic-coprecipitation separation of the selenium from urine in the presence of a high specific-activity75Se tracer. The processed urine samples are analyzed using NAA. The procedure was applied to 58 urine specimens longitudinally collected from 12 subjects consuming three different levels of selenium. A dose-response relationship was observed in urine as well as a high correlations with both serum and whole blood selenium concentrations.

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Authors and Affiliations

  1. Research Reactor Center, Missouri University, 65211, Columbia, MO, USA

    C. K. Baskett, V. L. Spate, M. M. Mason, C. L. Reams & J. S. Morris

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  1. C. K. Baskett
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  2. V. L. Spate
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  3. M. M. Mason
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  4. C. L. Reams
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  5. J. S. Morris
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Baskett, C.K., Spate, V.L., Mason, M.M. et al. The determination of selenium in urine. Journal of Radioanalytical and Nuclear Chemistry, Articles 179, 323–329 (1994). https://doi.org/10.1007/BF02040167

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  • DOI: https://doi.org/10.1007/BF02040167

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