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Cα-Methyl phenylglycine-based semi-synthetic ampicillin and cephalexin analogues

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Abstract

Reaction of the N-carboxyanhydride from Cα-methyl d-phenylglycine with either 6-aminopenicillanic acid or 7-amino-3-desacetoxy-cephalosporanic acid furnishes the corresponding ampicillin and cephalexin analogues. Neither the biological activity nor the chemical stability of these new semi-synthetic antibiotics are superior to those of their unmethylated counterparts.

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Authors
  1. Eric Mossel
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  2. Fernando Formaggio
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  3. Marco Crisma
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  4. Claudio Toniolo
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  5. Theo Sonke
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  6. Eric C. Roos
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  7. Quirinus B. Broxterman
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  8. Johan Kamphuis
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Mossel, E., Formaggio, F., Crisma, M. et al. Cα-Methyl phenylglycine-based semi-synthetic ampicillin and cephalexin analogues. Letters in Peptide Science 5, 43–48 (1998). https://doi.org/10.1023/A:1008806925287

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