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Rationale for the selection and use of in vitro assays to screen for chemopreventive agents

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Methods in Cell Science

Abstract

This issue reports the methods of twelve in vitro assays currently being used to screen potential chemopreventive agents for activity. These assays provide quantitative data to help determine the efficacy and prioritize agents for further development in whole animal screening. It is essential that such in vitro assays provide accurate, consistent, and relevant data to identify and prioritize agents with the most promise to prevent human cancer. The twelve assays presented in this volume are currently providing such data to the National Cancer Institute's Chemoprevention Program.

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References

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Authors and Affiliations

  1. Chemoprevention Branch, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland, USA

    Vernon E. Steele, Charles W. Boone, Ronald A. Lubet, Caroline S. Sigman & Gary J. Kelloff

Authors
  1. Vernon E. Steele
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  2. Charles W. Boone
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  3. Ronald A. Lubet
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  4. Caroline S. Sigman
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  5. Gary J. Kelloff
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Steele, V.E., Boone, C.W., Lubet, R.A. et al. Rationale for the selection and use of in vitro assays to screen for chemopreventive agents. Methods Cell Sci 19, 1–2 (1997). https://doi.org/10.1023/A:1009772307902

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  • DOI: https://doi.org/10.1023/A:1009772307902

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