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Recombinant human protein C, protein S and thrombomodulin as antithrombotics

  • Perspectives
  • Published:
Perspectives in Drug Discovery and Design

Summary

Over the last 10 years, much has been learned about the human protein C anticoagulation system, a key pathway in maintaining blood in a fluid state in vivo. Three major glycoproteins, namely protein C, protein S and thrombomodulin, are involved in this pathway. The aim of this article is to discuss therapeutic potentials and issues and challenges for developing recombinant protein C, protein S and soluble thrombomodulin as novel antithrombotics. We also briefly discuss other drug design strategies that may be employed in modulating the activity of the protein C anticoagulant pathway under pathological conditions.

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Abbreviations

HPC:

human protein C

HPS:

human protein S

aPC:

activated human protein C

rHPC:

recombinant human protein C

r-aPC:

recombinant activated human protein C

rHPS:

recombinant human protein S

TM:

thrombomodulin

TNF:

tissue necrosis factor

IL-1:

interleukin-1

Fuc:

fucose

Man:

mannose

GlcNAc:

N-acetylglucosamine

GalNAc:

N-acetylgalactosamine

NeuAc:

N-acetylneuraminic acid

Gla:

γ-carboxyglutamate

DIC:

disseminated intravascular coagulation

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  1. Cardiovascular Research, Lilly Research Laboratories, Eli Lilly and Company, 46285-1543, Indianapolis, IN, U.S.A.

    S. Betty Yan & Brian W. Grinnell

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Yan, S.B., Grinnell, B.W. Recombinant human protein C, protein S and thrombomodulin as antithrombotics. Perspectives in Drug Discovery and Design 1, 503–520 (1994). https://doi.org/10.1007/BF02171862

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