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The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration

  • Pharmacology
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Abstract

The pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent volume of distribution (V d) was 1.35 ± 0.18 L/kg and the body clearance (ClB) was 0.061 ± 0.009 L kg−1 h. After oral administration the half-life of absorption was 1.24 ± 0.30 h, and the calculated bioavailability was above 100%. Thet1/2β after oral administration was 18.51 ± 1.75 h, only a little longer than that after intravenous administration. The slow release formulation did not exhibit any advantage in prolonging thet1/2β of theophylline in the horse.

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  1. Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, cc 296, 1900, La Plata, Argentina

    J. O. Errecalde & M. F. Landoni

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  1. J. O. Errecalde
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  2. M. F. Landoni
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Errecalde, J.O., Landoni, M.F. The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration. Vet Res Commun 16, 131–138 (1992). https://doi.org/10.1007/BF01839010

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