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Cellular mechanisms of hypertrophic cardiomyopathy in spontaneously hypertensive rats (SHR)

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that the weight dynamics of the body, heart and left ventricular myocardium is similar in Wister rats and SHR, but the number of cardiomyocytes in the 5th and 24th weeks of postnatal development is considerably higher in Wistar rats than in SHR. The earlier maturation of cardiomyocytes in SHR rats leads to their reduced proliferative activity, thus blocking the growth of the cell population.

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Authors and Affiliations

  1. Laboratory of General Pathological Anatomy, Institute of Regional Pathology and Pathomorphology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk

    D. E. Semenov & L. M. Nepomnyashchikh

Authors
  1. D. E. Semenov
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  2. L. M. Nepomnyashchikh
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 1, pp. 93–95 January, 1994

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Semenov, D.E., Nepomnyashchikh, L.M. Cellular mechanisms of hypertrophic cardiomyopathy in spontaneously hypertensive rats (SHR). Bull Exp Biol Med 117, 96–99 (1994). https://doi.org/10.1007/BF02444092

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  • DOI: https://doi.org/10.1007/BF02444092

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