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Reaction of adrenal medulla to extreme factors of various nature

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on mice show that primary decrease in the catecholamine content in the adrenals 6 h and 1–2, and 4 days after immobilization stress is followed by catecholamine accumulation in the adrenal medulla. Practically the same dynamics within days 1–4 is observed after administration of a high dose of 5-fluorouracil; however, the restoration of the initial catecholamine level in mice treated with the cytostatic takes more than in stressed animals. These data suggests that high doses of 5-fluorouracil induce nonspecific activation of the sympathoadrenal system, presumably leading to adaptation to cytotoxic effects of 5-fluorouracil.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, USSR

    I. A. Khlusov, T. I. Fomina, A. M. Dygai & E. D. Gol'dberg

Authors
  1. I. A. Khlusov
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  2. T. I. Fomina
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  3. A. M. Dygai
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  4. E. D. Gol'dberg
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 293–295, March, 1997

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Khlusov, I.A., Fomina, T.I., Dygai, A.M. et al. Reaction of adrenal medulla to extreme factors of various nature. Bull Exp Biol Med 123, 255–256 (1997). https://doi.org/10.1007/BF02445417

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  • DOI: https://doi.org/10.1007/BF02445417

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