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Age-related characteristics of epithelial-muscular interactions in the rat trachea

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The interactions between epithelial and muscular cells of tracheal wall were studied by a mechanographic technique in rats of different ages. The state of the epithelium was assessed using hematoxylin-eosin stained sections. The epithelium-dependent relaxation was found to be most promounced in 10–12-week-old rats. It was not observed in younger rats probably due to the low sensitivity of guanylate cyclase to activating stimuli. Destructive changes in the respiratory epithelium after 24 weeks of life reduced the amplitude of epithelium-dependent relaxation in old rats.

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Authors and Affiliations

  1. Siberian Medical University, Tornsk, Russia

    M. V. Kuskov, L. V. Kapilevich, M. B. Baskakov & M. A. Medvedev

  2. Mental Health Institute, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    M. V. Kuskov, L. V. Kapilevich, M. B. Baskakov & M. A. Medvedev

Authors
  1. M. V. Kuskov
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  2. L. V. Kapilevich
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  3. M. B. Baskakov
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  4. M. A. Medvedev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 625–627, December, 1998

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Kuskov, M.V., Kapilevich, L.V., Baskakov, M.B. et al. Age-related characteristics of epithelial-muscular interactions in the rat trachea. Bull Exp Biol Med 126, 1197–1199 (1998). https://doi.org/10.1007/BF02447148

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  • DOI: https://doi.org/10.1007/BF02447148

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