Summary
In order to stimulate regenerative bone formation in adult mammals experiments were conducted in replacing cranial bone defects by ground cranial bone. In rats the homotransplanted bone grindings resolved in three weeks. In mice — more slowly — they were preserved for several months. Bone grindings stimulated transformation of local connective tissue into genuine bone tissue, and replaced cranial bone defects both in rats and mice.
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Polezhaev, L.V., Marveeva, A.I. & Zakharova, N.A. Cranial bone regeneration effected by transplantation of ground mammal bones. Bull Exp Biol Med 43, 484–488 (1957). https://doi.org/10.1007/BF00802719
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DOI: https://doi.org/10.1007/BF00802719