Abstract
Thymectomy performed on adult animals 6 months or more before infection withMycobacterium tuberculosis considerably reduces resistance to tuberculous infection; the longer the time after the operation, the greater the decrease in resistance. Disturbances of immunity connected mainly with damage to thymus-dependent cells (depopulation of the thymus-dependent zones, a decrease in the tuberculin sensitivity of the skin and the cytotoxic action of lymphocytes on antigen-containing target cells).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
M. M. Averbakh, V. A. Klyuev, and V. I. Litvinov, Byull. Éksp. Biol. Med., No. 5, 64 (1973).
Yu. M. Galkin and V. G. Dobkin, Éksp. Khir., No. 3, 26 (1975).
J. Fachet and D. Parrot, Clin. Exp. Immunol.,10, 661 (1972).
H. Folch and B. H. Waksman, J. Immunol.,109, 1046 (1972).
J. W. Kappler, P. C. Hunter, D. Jacobs, et al., J. Immunol.,113, 27 (1974).
H. F. Jeejeebhoy, Transplantation,12, 525 (1971).
D. Metcalf, Brit. J. Haemat.,6, 324 (1960).
J. F. A. P. Miller, Proc. Roy. Soc. B.,156, 415 (1962).
T. S. Rothwell and W. G. Spector, J. Path.,108, 15 (1972).
E. Simpson and H. Cantor, Europ. J. Immunol.,5, 337 (1975).
Rights and permissions
About this article
Cite this article
Averbakh, M.M., Galkin, Y.M., Litvinov, V.I. et al. Immunity to tuberculosis in thymectomized adult mice. Bull Exp Biol Med 81, 894–895 (1976). https://doi.org/10.1007/BF00803015
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00803015