Abstract
Malate dehydrogenase is present in most mammalian tissues in both supernatant and mitochondrial forms. Although genetic variation for the supernatant form has not been observed in the mouse, electrophoretic variants caused by alleles at the mitochondrial locus (Mor-1) have been previously described. We have located this locus 11.0±2.9 cM from the β-glucuronidase structural gene, Gus, on chromosome 5. The gene order is Hm-Pgm-1-rd-bf-Gus-Mor-1. Thus Mor-1 is presently the most distal marker on chromosome 5. Three different nuclear loci for mitochondrial enzymes (Mod-2, Got-2, and Mor-1) have now been mapped in the mouse, all on different chromosomes.
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This investigation was supported by U.S. Atomic Energy Commission Contract AT(11-1)-3267, by Grant GM 19656 from the National Institute of General Medical Sciences, by Contracts NO1-ES4-2156 and NO1-ES4-2159 from the National Institute of Environmental Health Sciences, and by Training Grant CA-05013 from the National Cancer Institute to The Jackson Laboratory. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.
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Womack, J.E., Hawes, N.L., Soares, E.R. et al. Mitochondrial malate dehydrogenase (Mor-1) in the mouse: Linkage to chromosome 5 markers. Biochem Genet 13, 519–525 (1975). https://doi.org/10.1007/BF00484911
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DOI: https://doi.org/10.1007/BF00484911