Skip to main content
SpringerLink
Log in

Research potential of a unique xenograft model of human proliferative breast disease

  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

A workshop on the ‘Research potential of a unique xenograft model of human proliferative breast disease’ was held at the Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, in November of 1998. The accumulated information and current experimental findings on the MCF10AT model of preneoplastic, proliferative breast disease were reviewed. Discussions focused on the relevance of the model to clinical breast cancer and on the most profitable lines of further research to strengthen its utility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Page DL, Dupont WD: Anatomic markers of human premalignancy and risk of breast cancer. Cancer 66: 1326–1335, 1990

    Google Scholar 

  2. Dawson PJ, Wolman SR, Tait L, Heppner GH, Miller FR: MCF10AT: A model for the evolution of cancer from proliferative breast disease. Am J Path 148: 313–319, 1996

    Google Scholar 

  3. Shekhar PVM, Nangia-Makkar P, Wolman SR, Tait L, Heppner GH, Visscher DW: Direct action of estrogen on sequence of progression of human preneoplastic breast disease. Am J Path 152: 1129–1132, 1998

    Google Scholar 

  4. Heppner GH, Wolman SR: MCF-10AT: A model for human breast cancer development. The Breast J 5: 1–8, 1999

    Google Scholar 

  5. Shekhar PVM, Welte R, Christman JK, Wang H, Werdell J: Altered p53 conformation: a novel mechanism of wild-type P53 functional inactivation in a model for early human breast cancer. Int J Oncol 11: 1087–1094, 1997

    Google Scholar 

  6. Tsai YC, Lu Y, Nichols PW, Zlotnikov C, Jones PA, Smith HS: Contiguous patches of normal human mammary epithelium derived from a single stem cell: implications for breast carcinogenesis. Cancer Res 56: 402–404, 1996

    Google Scholar 

  7. Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS: Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274: 2057–2059, 1996

    Google Scholar 

  8. Rosenberg CL, Larson PS, Romo JD, De Las Morenas A, Faller DV: Microsatellite alterations indicating monoclonality in atypical hyperplasias associated with breast cancer. Human Path 28: 214–219, 1997

    Google Scholar 

  9. Pauley RJ, Soule HD, Tait L, Miller FR, Wolman SR, Dawson PJ, Heppner GH: The MCF10 family of spontaneously immortalized human breast epithelial cell lines and models of neoplastic progression. Eur J Cancer Prevention 2: 67–76, 1993

    Google Scholar 

  10. Roman CA, Cherry SR, Baltimore D: Complementation of V (D) J recombination deficiency in RAG-1 (-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1. Immunity 7: 13–24, 1997

    Google Scholar 

  11. Visonneau S, Cesano A, Torosian MH, Miller EJ, Santoli D: Growth characteristics and metastatic properties of human breast cancer xenografts in immunodeficient mice. Am J Path 152: 1299–1311, 1998

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Karmanos Cancer Institute, Wayne State University, Detroit, MI

    Gloria H. Heppner

  2. Uniformed Services University of the Health Sciences, Bethesda, MD

    Sandra R. Wolman

  3. Baylor College of Medicine, Houston, TX

    Jeffrey Rosen

  4. National Cancer Institute, Bethesda, MD, USA

    David Salomon, Gil Smith & Suresh Mohla

Authors
  1. Gloria H. Heppner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sandra R. Wolman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jeffrey Rosen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David Salomon
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gil Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Suresh Mohla
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heppner, G.H., Wolman, S.R., Rosen, J. et al. Research potential of a unique xenograft model of human proliferative breast disease. Breast Cancer Res Treat 58, 183–186 (1999). https://doi.org/10.1023/A:1006344019706

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1006344019706

Search

Navigation