Summary
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1.
The effect of transient forebrain ischemia on endothelin-1 (ET-1) and endothelin-3 (ET-3) production in the hippocampus of stroke-prone spontaneously hypertensive rats (SHRSPs) was investigated using immunohistochemical techniques.
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2.
In SHRSPs subjected to 10-min bilateral carotid occlusion, neuronal degeneration in the CA1 pyramidal cell layer of the hippocampus was detectable at 4 days and remarkable at 7 days after reperfusion.
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3.
Coinciding with neuronal degeneration, ET-1- and ET-3-like immunoreactivities were intense in the CA1 pyramidal-cell layer, the stratum lacunosum moleculare, and the CA4 subfield of the hippocampus. Almost all of the immunostained cells had morphological characteristics of astrocytes.
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4.
The possibility that ET has a role in the development of neuronal cell death following transient forebrain ischemia warrants further attention.
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Yamashita, K., Kataoka, Y., Niwa, M. et al. Increased production of endothelins in the hippocampus of stroke-prone spontaneously hypertensive rats following transient forebrain ischemia: Histochemical evidence. Cell Mol Neurobiol 13, 15–23 (1993). https://doi.org/10.1007/BF00712986
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DOI: https://doi.org/10.1007/BF00712986