Summary and conclusions
The potassium iodide saliva test, as described, is as useful as the test meal method1 for determining the rate of gastric emptying. When administered orally, atropine (1 mg.) is approximately equivalent to heteronium bromide (4.2 mg.), insofar as effect on gastric emptying is concerned.
The test meal method for determining gastric secretory activity demonstrated that, when administered orally, heteronium bromide had a significantly greater effect on gastric secretion than did atropine. This suggests that it may be possible to separate the effects of anticholinergic drugs on motility from the effects on secretion.
The doses of atropine and heteronium bromide used in this study did not produce any unusual or excessive untoward reactions. In these single dose studies they were equally acceptable to the patients.
This study was designed as a pharmacologic test using human subjects. It was not an experiment in therapeutics; therefore, the doses used were not in accord with those recommended for routine patient care. No implication is intended that these doses be used therapeutically.
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The authors express their appreciation to Mr. Ralph Carmichael for the analysis of samples, the medical staff of the Marion County General Hospital, and to Mrs. Sharon Shariatzadeh and Mrs. Hilda Banks for their help and cooperation.
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Chernish, S.M., Young, E.B., Rosenak, B.D. et al. A comparison of two methods of measurement of gastric emptying time. Digest Dis Sci 12, 761–774 (1967). https://doi.org/10.1007/BF02236241
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DOI: https://doi.org/10.1007/BF02236241