Abstract
The neutralizing capacity of two antacids (Alucol®=A, Syntrogel®=S), differing both in their composition and theoretical neutralizing capacity, was evaluatedin vitro andin vivo.In vitro at pH 3.5, 1 ml of A or S neutralizes 3.9 and 1.6 meq of acid, respectively, in an aqueous solution. When testedin vivo in the absence of food during near maximal acid secretion, induced by impromidine, 60 ml of either A or S reduced the 4-hr mean H+ activity by 83% and 65%, respectively. In contrast, the reduction of the 12-hr H+ activity observed after repeated administration of 30–60 ml of A or S at the end of the postprandial hour failed to reach significance with both preparations. This suggests that interaction with food produces a considerable loss ofin vivo antacid neutralizing capacity, not quantitatively predictable fromin vitro tests.
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Fordtran JS, Morawski SG, Richardson CT:In vivo andin vitro evaluation of liquid antacids. N Engl J Med 288: 923–928, 1973
Güller R: Pufferkapazität und Kosten der flüssigen Antazida. Schweiz Med Wochenschr 107:807–810, 1977
Holtermüller KH, Böhlen E, Castro M, Weis HJ: Ueberlegungen zur Therapie mit Antazida. Med Klin 72:1229–1241, 1977
Halter F, Huber R, Häcki WH, Varga L: Intragastric interaction between protein and antacids. Acta Hepato Gastroenterol 25:499–500, 1978
Halter F, Huber R, Häcki WH, Varga L, Bachmann C: Effect of food on antacid neutralizing capacity in man. Eur Clin Invest 12:209–217, 1982
Halter F, Häcki WH, Varga L: A vailability of antacids in a meat extract.In Antacids in the Eighties. F. Halter (ed). München, Urban & Schwarzenberg, 1982, pp 35–40
Witzel L, Heitz P, Halter F, Olah AJ, Varga L, Werner O, Häcki WH: Effects of prolonged administration of metiamide on serum gastrin, gastrin contents of the antrum and gastric corpus and G-cell population in the rat. Gastroenterology 76:945–949, 1977
Häcki WH, Gyr K, Kayasseh L, Halter F: Secretin und pankreatisches Polypeptid nach Ansäuern des Duodenums beim Menschen. Z Gastroenterol 11:17, 749–17, 752, 1979
Bangerter U, Schlup M, Liechti M, Häcki WH, Halter F: Clinical experience with Impromidine, a highly selective H2 receptor agonist. Digestion 22:196–202, 1981
Peterson WL, Barnett C, Feldman M, Richardson CT: Reduction of 24-hour gastric acidity with combination drug therapy in patients with duodenal ulcer. Gastroenterology 77:1015–1020, 1979
Goldberg HI, Dodds WJ, Gee S, Montgomery C, Zboralske FF: Role of acid and pepsin in acute experimental esophagitis. Gastroenterology 56:223–230, 1969
Fordtran JS, Collyns JAH: Antacid pharmacology in duodenal ulcer. N Engl J Med 274:921–927, 1966
Carlson GL, Malagelada JR: Chemistry of the antacids: Its relevance to antacid therapy.In Antacids in the Eighties. F. Halter (ed). München, Urban & Schwarzenberg, 1982, pp 7–16
Hurwitz A, Robinson RG, Vats TS, Whittier FC, Herrin WF: Effects of antacids on gastric emptying. Gastroenterology 55:462–468, 1975
Deering TB, Carlson GL, Malagelada JR, Duenes JR, McCall JT: Fate of oral neutralizing antacids and its effect on postprandial gastric secretion and emptying. Gastroenterology 66:986–990, 1970
Becker HD, Degenhard D: Bioverfügbarkeit und Pufferkapazität von Antazida. Fortschr Med 99:1318–1320, 1981
Walther C, Herzog P, Hissnauer KH, Kühl HJ, Holtermüller KH: Ein Vergleich der Neutralisationskapazität von Antazida in verdünnter Salzsäure und salzsaurer Peptonlösung. Z Gastroenterolog 20:263–272, 1982
Wissenschaftl. Tabellen Geigy, Band 1, Basel, Ciba-Geigy 1977, p. 253
Gibaldi M, Kahnig JL, Amsel L: Criticalin vitro factors in the evaluation of gastric antacids II. J Pharm Sci 53:1375–1377, 1964
Fordtran JS: Acid rebound. N Engl J Med 279:900–905, 1968
Barreras RF: Acid secretion after calcium carbonate in patients with duodenal ulcer. N Engl J Med 282:1402–1405, 1970
Lehmann JA, Walsh JA, Isenberg JI: Stimulation of gastric secretion and gastrin release by single oral doses of calcium carbonate in man. N Engl J Med 289:555–558, 1973
Brodie MJ, Ganguli P, Fine A, Thompson TJ: Effect of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man. Gut 18:111–114, 1977
Etienne A, Fimmel CJ, Rey JB, Blum AL: Long-lasting effect of an Al-magnesium liquid antacid on nocturnal intragastric secretion recorded by continuous pH-metry. Gastroenterology 86:1071, 1984
Peterson WL, Sturdevant RAL, Frankl HD, et al: Healing of duodenal ulcer with antacid regimen. N Engl J Med 297:341–345, 1977
Marks IN: Healing of peptic ulcers on conventional antacid therapy with or without butriptyline. S Afr Med J 55:331–334, 1979
Lam SK, Lam KC, Lai CL, et al: Treatment of duodenal ulcer with antacid and sulpiride. Gastroenterology 76:315–322, 1979
Berstad A, Rydning A, Aadland E, et al: Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scand J Gastroenterol 17:953–959, 1982
Editorial: How innocuous is the white medicine? Br Med J 2:405, 1975
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Berchtold, P., Reinhart, W.H., Niederhäuser, U. et al. In vitro tests overestimatein vivo neutralizing capacity of antacids in presence of food. Digest Dis Sci 30, 522–528 (1985). https://doi.org/10.1007/BF01320257
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DOI: https://doi.org/10.1007/BF01320257