Abstract
Helicobacter pylori colonization of the gastric mucosa is strongly associated with chronic nonspecific gastritis; moreover, there is evidence to suggest thatH. pylori may cause this form of gastritis. However, there is little or no information on the prevalence ofH. pylori in specific forms of gastritis. Our hypothesis was that ifH. pylori was pathogenic in chronic nonspecific gastritis, organisms would be found frequently in this type of gastritis but infrequently in specific forms of gastritis. Prevalence rates ofH. pylori were determined independently in patients with eosinophilic and Crohn's gastritis, Menetrier's disease, and chronic nonspecific gastritis. The prevalence ofH. pylori in patients with chronic nonspecific gastritis was 71%, whereas the organism was not identified in patients with any form of specific gastritis. This finding further supports the accumulating evidence thatH. pylori is a primary pathogenic factor in chronic nonspecific gastritis.
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Loffeld RJLF, Potters HVPJ, Arends JW, Stobberingh E, Flendrig JA, van Spreeuwel JP:Campylobacter-associated gastritis in patients with non-ulcer dyspepsia. J Clin Pathol 4:85–88, 1988
Marshall BJ, McGechie DB, Rogers PA, Glancy RJ: PyloricCampylobacter infection and gastroduodenal disease. Med J Aust 142:439–444, 1985
Dooley CP, Cohen H: The clinical significance ofCampylobacter pylori. Ann Intern Med 108:70–79, 1988
Varis K: Gastritis—a misused term in clinical gastroenterology. Scand J Gastroenterol 23(suppl 155):53–58, 1988
Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, P-Perez GI, Blaser MJ: Prevalence ofHelicobacter pylori and histologic gastritis in asymptomatic persons. N Engl J Med 321:1562–1566, 1989
Lepore MJ, Smith FB, Bonanno CA:Campylobacter-like organisms in a patient with Menetrier's disease. Lancet 1:466, 1988
O'Connor HJ, Axon ATR, Dixon MF:Campylobacter-like organisms unusual in type A (pernicious anaemia) gastritis. Lancet 2:1091, 1984
Flejou J-F, Bahame P, Smith AC, Stockbrugger RW, Rode J, Price AB: Pernicious anaemia andCampylobacter-like organisms; is the gastric antrum resistant to colonisation? Gut 30:60–64, 1989
Dixon MF, Wyatt JI, Burke DA, Rathbone BJ: Lymphocytic gastritis—relationship toCampylobacter pylori infection. J Pathol 154:125–132, 1988
Drumm B, Sherman P, Cutz E, Karmali M: Association ofCampylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med 316:1557–1561, 1987
Buck GE, Gorley WK, Lee WK, Subramanyam K, Latimer JM, DiNuzzo AR: Relation ofCampylobacter pyloridis to gastritis and peptic ulcer. J Infect Dis 153:664–669, 1986
Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ: Attempt to fulfill Koch's postulates for pyloric campylobacter. Med J Aust 142:436–439, 1985
Morris A, Nicholson G: Ingestion ofCampylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol 82:192–199, 1987
Morgan D, Kraft W, Bender M, Pearson A: Nitrofurans in the treatment of gastritis associated withCampylobacter pylori. Gastroenterology 95:1178–1184, 1988
Rathbone BJ, Wyatt JI, Worsley BW, Shires SE, Trejdosiewica LK, Heatley RV, Losowsky MS: Systemic and local antibody responses to gastricCampylobacter pyloridis in non-ulcer dyspepsia. Gut 27:642–647, 1986
Bode G, Malfertheiner P, Dischuneit H: Pathogenetic implications of ultrastructural findings inCampylobacter pylori related gastroduodenal disease. Scand J Gastroenterol 23(suppl 142):25–39, 1988
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This work was supported in part by the Mayo Digestive Diseases Center Grant (DK34988) from the National Institutes of Health, United States Public Health Service.
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Ormand, J.E., Talley, N.J., Shorter, R.G. et al. Prevalence ofHelicobacter pylori in specific forms of gastritis. Digest Dis Sci 36, 142–145 (1991). https://doi.org/10.1007/BF01300747
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DOI: https://doi.org/10.1007/BF01300747