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Arachidonic acid aggregates neutrophils

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Abstract

Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5,8,11,14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.

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Authors and Affiliations

  1. University of Connecticut Health Center, 06032, Farmington, Connecticut

    J. T. O'Flaherty, H. S. Showell, E. L. Becker & P. A. Ward

Authors
  1. J. T. O'Flaherty
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  2. H. S. Showell
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  3. E. L. Becker
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  4. P. A. Ward
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Additional information

This work was supported in part by NIH grants AI-09651, HL-05474, HL-22437 and HL-07202.

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O'Flaherty, J.T., Showell, H.S., Becker, E.L. et al. Arachidonic acid aggregates neutrophils. Inflammation 3, 431–436 (1979). https://doi.org/10.1007/BF00913500

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