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Quaternary Structure of Nucleoside Diphosphate Kinases

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Abstract

Nucleoside (NDP) diphosphate kinases are oligomeric enzymes. Most are hexameric, but somebacterial enzymes are tetrameric. Hexamers and tetramers are constructed by assemblingidentical dimers. The hexameric structure is important for protein stability, as demonstratedby studies with natural mutants (the Killer-of-prune mutant ofDrosophila NDP kinase andthe S120G mutant of the human NDP kinase A in neuroblastomas) and with mutants obtainedby site-directed mutagenesis. It is also essential for enzymic activity. The function of the tetrameric structure is unclear.

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Authors and Affiliations

  1. Institut de Biochimie et Génétique Cellulaires, UMR 5095, University of Bordeaux-2 and CNRS, 33077, Bordeaux, France

    Ioan Lascu

  2. Istituto Pasteur-Fondazione Cenci-Bolognetti and Dipartimento di Scienze Biochimiche, Università La Sapienza, 00185, Roma, Italy

    Anna Giartosio

  3. Institut de Biochimie et Génétique Cellulaires, UMR 5095, University of Bordeaux-2 and CNRS, 33077, Bordeaux, France

    Stéphane Ransac & Muriel Erent

  4. National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    Muriel Erent

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  1. Ioan Lascu
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  4. Muriel Erent
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Lascu, I., Giartosio, A., Ransac, S. et al. Quaternary Structure of Nucleoside Diphosphate Kinases. J Bioenerg Biomembr 32, 227–236 (2000). https://doi.org/10.1023/A:1005580828141

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