Summary
The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity)immunological functions, by counting the Cr51 release in Chang liver and K 562 cell cultures, respectively. These parameters were also evaluated in 24 healthy donors as control, in 24 patients affected by bladder cancer and in nine cases of kidney cancer.
Our data show, pre-operatively, a statistically significant impairment of ADCC and SLMC activity in glioma patients as compared both with controls, bladder and kidney cancer patients.
The particular impairment of K and NK functions in gliomas is discussed with regard to the specific features of Central Nervous System malignancies. An improvement of ADCC activity was also found in the post-operative samples. This finding confirms other reports about partial restoring of altered immunocompetence after surgery, suggesting a link between extention of tumor mass and impaired immunological reactions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Antonelli P, Stewart II W, Dupont B: Distribution of natural killer activity in peripheral blood, cord blood, thymus, lymphonodes and spleen and the effect of in vitro treatment with interferon preparation. Clin Immunol Immunopath 19:161–169, 1981.
Apuzzo MLJ, Mitchell MS: Immunological aspects of intrinsic glial tumors. J Neurosurg 55:1–18, 1981.
Böyum A: Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 21:1–109, 1968.
Braun DP, Penn RD, Flannery AM, Harris JE: Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas. Neurosurgery 10:203–209, 1982.
Brooks WH, Latta RB, Mahaley MS, Roszman TL, Dudka L, Skaggs C: Immunobiology of primary intracranial tumors, part V: correlation of a lymphocyte index and clinical status. J Neurosurg 54:331–337, 1981.
Brooks WH, Netzky MG, Normansell DE, Horwitz DA: Depressed cell mediated immunity in patients with primary intracranial tumors. J Exp Med 136:1631–1647, 1972.
Brooks WH, Roszman TL, Rogers AS: Impairment of rosette forming T lymphocytes in patients with primary intracranial tumors. Cancer 37:1869–1873, 1976.
Eremin O, Coombs RR, Plumb D: Characterization of the human natural killer cells in blood and lymphoid organs. Int J Cancer 21:42–50, 1978.
Heberman RB, Ortaldo JR, Bonnard GDL: Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature 277:221–223, 1979.
Hill NO, Khan A, Loeb: Clinical trials of high dose human lekocyte interferon. J Clin Hematol Oncol 9:297–299, 1979.
Gately MK, Glaser M, McCarron RM, Dick SJ, Dick MD, Mettetal RW, Kornblith PL: Mechanism by which human glioma can escape cellular immune attack. Acta Neurochir 64:175–197, 1982.
Gerosa MA, Olivi A, Rosenblum ML, Semenzato GP, Pezzutto A: Impaired immunocompetence in patients with malignant gliomas: the possible role of Tg-lymphocytes subpopulations. Neurosurgery 10:571–573, 1982.
Grossi CE, Cadoni A, Zicca A, Leprini A, Ferrarini M: Large granular lymphocytes in human peripheral blood: ultrastructural and cytochemical characterization of granules. Blood 59:277–283, 1982.
Gupta S, Fernandes G, Nair M, Good RA: Spontaneous and antibody dependent cell-mediated cytotoxicity by T-cell subpopulations. Immunology 10:5137–5141, 1978.
Kall MA, Koren HS: Heterogeneity of human natural killer cell populations. Cell Immunol 40:58–68, 1978.
Kall MA, Koren HS: Human natural killing: evidence for both serum-independent and serum dependent cytotoxic mechanisms. Cell Immunol 47:57–68, 1979.
Klein E, Vanky F, Vase BM, Fogg M: NK and tumor recognizing lymphocyte activity in tumor patients. Haematologia (Budap) 12:107–112, 1978–79.
Mahaley MS, Brooks WH, Roszman TL, Danel DB, Dudka L, Richardson S: Immunobiology of primary intracranial tumors, part I: studies of cellular and humoral general immunocompetence of brain tumor patients. J Neurosurg 46: 467–476,1977.
Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD: Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T-cell bearing receptors for IgM or IgG. J Exp Med 146:184–200, 1977.
Neuwelt EA, Clark WK: Clinical Aspects of Neuroimmunology. William and Wilkins, Baltimore, 1978, pp 148–149.
Roszman TL, Brook WH: Immunobiology of primary intracranial tumors, part III: demonstration of a qualitative lymphocyte abnormality in patients with brain tumors. Clin Exp Immunol 39:395–402, 1980.
Servadei F, Parente R, Spagnolli F, Gaist G, Padovani R, Bucci M, Steiner L: Immunological monitoring of patients affected by anaplastic gliomas concerning the effects of surgery, radio- and chemotherapy. Acta Neurochir 60: 71–80, 1982.
23.Kadish AS, Doyle AT, Steinhauer EH, Ghossein NA: Natural killer cytoxicity and interferon production in human cancer: deficient natural killer activity and normal interferon production patients with advanced disease. J Immunol 127/5:1817–1822, 1981.
Steinhauer EH, Doyle AT, Reed J, Kadish AS: Defective natural cytoxicity in patients with cancer: normal number of effector cells but decreased recycling capacity in patients with advanced desease. J Immunol 129/5:2255–2259, 1982.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Servade, F., Parente, R., Bucci, M. et al. Particular features of cell-mediated immunity in patients with anaplastic gliomas. J Neuro-Oncol 1, 327–332 (1983). https://doi.org/10.1007/BF00165716
Issue Date:
DOI: https://doi.org/10.1007/BF00165716