Abstract
Central neurocytoma is considered to be a benign intracranial neoplasm, but little is known about the biological behavior of this type of tumor.Proliferative activity of central neurocytoma was measured in 10 cases using MIB-1 staining for Ki-67 antigen.The MIB-1 staining value varied from < 0.1% to 5.6%, to indicating that some of these tumors have proliferative potential similar to that of anaplastic astrocytoma or malignant meningioma. Thebromodeoxyuridine labeling index (BUdR LI, BrdU LI) was measured in 2 cases and the results correlated well with those of the MIB-1 analysis. Tumor volume doubling time (Td) measured in one case was 358 days which is similar to that of malignant meningioma.In one case, the MIB-1 value taken beforeand after 58 Gy of radiation treatment decreased markedly from 5.6%to 0.2%. The other 9 cases were also treated by radiation therapy (50—60 Gy) and no tumor recurrence was observed during follow-up periods ranging from 23 to 160 months. Another two patients with partially removed and 3 with subtotallyremoved tumors showing relatively high MIB-1 values might also have benefited from radiation therapy.
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Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellissier JF, Toga M: Centrala neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol (Berl) 56: 151–156, 1982
Hassoun J, Soeylemezoglu F, Gambarelli D, Figarella-Bragner D, von Ammon K, Kleihues P: Central neurocytoma: A synopsis of clinical and histological features. Brain Pathol 3: 297–306, 1993
Barbosa MD, Balsitis M, Jaspan T, Lowe J: Intraventricular neurocytoma: a clinical and pathological study of three cases and review of the literature. Neurosurgery 26: 1045–1054, 1990
Hara A, Araki Y, Shinoda J, Hirayama H, Niikawa S, Sakai N, Yamada H: Central neurocytoma: proliferative assessment by nucleolar organizer region staining. Surg Neurol 39: 343–347, 1993
Zentner J, Peiffer J, Roggendorf W, Grote E, Hassler W: Periventricular neurocytoma: a pathological entity. Surg Neurol 38: 38–42, 1992
von Deimling A, Kleihues P, Saremaslani P, Yasargil MG, Spoerri O, Sudhof TC, Wiestler OD: Histogenesis and differentiation potential of central neurocytomas. Lab Invest 64: 585–591, 1991
Yasargil MG, von Ammon K, von Diemling A, Valavanis A, Wichmann W, Wiestler OD: Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg 76: 32–37, 1992
Catteretti G, Becker M, Key G, Duchrow M, Schlueter C, Galle J, Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB1and MIB3) detect proliferating cells in microwave-processed formalin fixed paraffin section. J Pathol 168: 357–363, 1992
Gardes J, Schwab U, Lemke H, Stein H: Production of a mouse monoclonal antibody, reaction with a human nuclear antigen associated with cell proliferation. Int J Cancer 31: 13–20, 1983
Karamitopoulou E, Perentes E, Damantis I, Maraziotis T: Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal antibody on archival material. Acta Neuropathol 87: 47–54, 1994
Ohta M, Iwaki T, Kitamoto T, Takeshita I, Tateishi J, Fukui M: MIB1 staining index and scoring of histologic features in meningioma. Cancer 74: 3176–3189, 1994
Onda K, Davis RL, Shibuya M, Wilson CB, Hoshino T: Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas. Cancer 74: 1921–1926, 1994
Fujimaki T, Matsutani M, Nakamura O, Asai A, Funada N, Koike M, Segawa H, Aritake F, Fukushima T, Houjo S, Tamura A, Sano K: Correlation between bromodeoxyuridine labeling indices and patient prognosis in cerebral astrocytic tumors of adults. Cancer 67: 1629–1634, 1991
Casadei GP, Arrigoni GL, Versari P, Gambacorta M, Giangaspero F: Central neurocytoma. A clinico-pathologic study of five cases. Tumori 77: 323–327, 1991
Khoshyomn S, Maier H, Morimura T, Kitz K, Budka H: Immunostaining for proliferating cell nuclear antigen: its role in determination of proliferation in routinely processed human brain tumor specimens. Acta Neuropathol 86: 582–589, 1993
Morimura T, Kitz K, Budka H: In situanalysis of cell kinetics in human brain tumors: Immunocytochemical study of S phase cells by a new in vitrobromodeoxyuridine-labeling technique, and of proliferating pool cells by monoclonal antibody Ki-67. Acta Neuropathol p. 276–282, 1989
Morimura T, Kitz K, Stein H, Budka H: Determination of proliferative activities in human brain tumor specimens: a comparison of three methods. J Neuro-Oncol 10: 1–11, 1991
Matsutani M, Nakamura O, Fujimaki T, Nagashima T, Miyaki M: Growth potential of malignant meningiomas–BUdR labeling indices and oncogene amplification (in Japanese). Brain Tumor Pathol 7: 57–61, 1990
Kim DG, Chi JG, Park SH, Chang KH, Lee SH, Jung HW, Kim HJ, Cho BK, Choi KS, Han DH: Intraventricular neurocytoma: clinicopathological analysis of seven cases. J Neurosurg 76: 759–765, 1992
Hall P, Richards M, Gregory W, d’Ardenne A, Lister T, Stansfeld A: The prognostic value of Ki-67 immunostaining in non-Hodgkin’s lymphoma. J Pathol 154: 223–235, 1988
Shepherd N, Richman P, England J: Ki-67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlation. J Pathol 155: 213–219, 1988
Couldwell W, Weiss M, Law R, Hinton DR: Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas. J Neurosurg 82: 461–468, 1995
Nagashima T, DeArmond S, Murovic J, Hoshino T: Immunohistochemical demonstration of S-phase cells by anti-bromodeoxyuridine monoclonal antibody in human brain tumor tissues. Acta Neuropathol (Berl) 67: 155–159, 1985
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Fujimaki, T., Matsuno, A., Sasaki, T. et al. Proliferative activity of central neurocytoma: Measurement of tumor volume doubling time, MIB-1 staining index and bromodeoxyuridine labeling index. J Neurooncol 32, 103–109 (1997). https://doi.org/10.1023/A:1005740205113
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DOI: https://doi.org/10.1023/A:1005740205113