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Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation

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Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

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Authors and Affiliations

  1. Institute of Pharmacology, University and ETH Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    H. Mohler, F. Knoflach, J. Paysan, K. Motejlek, D. Benke, B. Lüscher & J. M. Fritschy

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  1. H. Mohler
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  2. F. Knoflach
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  4. K. Motejlek
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  5. D. Benke
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  7. J. M. Fritschy
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Mohler, H., Knoflach, F., Paysan, J. et al. Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation. Neurochem Res 20, 631–636 (1995). https://doi.org/10.1007/BF01694546

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  • DOI: https://doi.org/10.1007/BF01694546

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