Zusammenfassung
Mit einer fluorimetrischen Methode wird durch Bestimmung von Dopamin nachgewiesen, daß der Herzmuskel des Meerschweinchens Dopa zu Dopamin decarboxylieren kann. Die Decarboxylase ist im Zellsaft lokalisiert. Ihre Aktivität ist gegenüber anderen Organen klein.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Sutherland, E. W., andT. W. Rall: The relation of adenosine-3′,5′-phosphate and phosphorylase to the actions of catecholamines and other hormones. Pharmacol. Rev.12, 265–299 (1960).
Bing, R. J., A. Siegel, I. Unger andM. Gilbert: Metabolism of the human heart. II. Metabolism of fats, proteins and ketones. Amer. J. Med.16, 504–551 (1954).
Gordon jr. R. S., andA. Cherkes: Production of unesterified fatty acids from isolated rat adipose tissue incubated in vitro. Proc. Soc. exp. Biol. (N.Y.)97, 150–151 (1958).
Wool, J. G., M. S. Goldstein, E. R. Ramey andR. Levine: Role of epinephrine in the physiology of fat mobilization. Amer. J. Physiol.178, 427–432 (1954).
Raab, W.: The adrenergic-cholinergic control of cardiac metabolism and function. Fortschr. Kardiol.1, 65–152 (1956).
Dengler, H. J., H. E. Spiegel andE. O. Titus: Uptake of tritium-labelled norepinephrine in brain and other tissues of cat in vitro. Science133, 1072–1073 (1961).
Axelrod, J., H. Weil-Malherbe andR. Tomchick: The physiological dispoisition of H3-epinephrine and its metabolite metanephrine. J. Pharmacol. exp. Ther.127, 251–256 (1959).
Paasonen, M. K., andO. Krayer: The release of norepinephrine from the mammalian heart by reserpine. J. Pharmacol. exp. Ther.123, 153–160 (1958).
Burn, J. H., andM. J. Rand: The action of sympathomimetic amines in animals treated with reserpine. J. physiol. (Lond.)144, 314–336 (1958).
Cass, R., R. Kuntzman andB. B. Brodie: Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent. Proc. Soc. exp. Biol. (N.Y.)103, 871–872 (1960).
Butterfleld, J. L., andJ. A. Richardson: Acute effects of guanethidin on myocardial contractility and catecholamine levels. Proc. Soc. exp. Biol. (N.Y.)106, 259–262 (1961).
Porter, C. C., J. A. Totaro andC. M. Leiby: Some biochemical effects of α-methyl-3,4-dihydroxyphenylalanine and related compounds in mice. J. Pharmacol. exp. Ther.134, 139–145 (1961).
Hess, W. M., R. H. Connamacher, M. Ozaki andS. Udenfriend: The effects of α-methyl-dopa and α-methyl-meta-tyrosine on the metabolism of norepinephrine and serotonin in vivo. J. Pharmacol. exp. Ther.134, 129–138 (1961).
Axelrod, J., andM. H. Laroche: Inhibition of 0-methylation of epinephrine and norepinephrine in vitro and in vivo. Science130, 800 (1959).
Crout, J. R.: Inhibition of catechol-0-methyl-transferase by pyrogallol in the rat. Biochem. Pharmacol.6, 47–50 (1961).
Vendsalu, A.: Studies of adrenaline and noradrenaline in human plasma. Acta physiol. scand.49, Suppl. 173 (1960).
Carlsson, A., andB. Waldeck: A fluorimetric method for the determination of dopamine (3-hydroxytyramine). Acta physiol. scand.44, 293–298 (1958).
Langemann, H., u.H. Ackermann: Über die Aktivität der Aminosäurendecarboxylasen im Gehirn des Menschen. Helv. physiol. pharmacol. Acta19, 399–406 (1961).
Langemann, H.: Unveröffentlichte Resultate.
Udeneriend, S.: In: Fluorescence assay in biology and medicine,, p. 158. N.Y. u. London: Academic Press 1962.
Potter, L. T., andJ. Axelrod: Intracellular localisation of catecholamines in tissues of the rat. Nature (Lond.)194, 581–582 (1962).
Author information
Authors and Affiliations
Additional information
Herrn Prof. Dr. med. H.Fischer zum 70. Geburtstag gewidmet.
Rights and permissions
About this article
Cite this article
Müller, P.B., Langemann, H. Decarboxylierung von Dopa durch Herzmuskel von Meerschweinchen. Klin Wochenschr 40, 911–913 (1962). https://doi.org/10.1007/BF01482936
Issue Date:
DOI: https://doi.org/10.1007/BF01482936