Summary
An enzyme reaction in human platelets is demonstrated which possesses the properties of protein-phosphokinases isolated from other cells: phosphorylation of basic proteins in phosphoserine and -threonine linkages, magnesium dependency and stimulation by adenosine 3′,5′-monophosphate. It is suggested that this enzyme might be responsible for the expression of the cAMP effects on the platelets.
Zusammenfassung
In menschlichen Blutplättchen wurde eine Enzymreaktion gefunden, die die Eigenschaften typischer Proteinkinasen anderer Zellen und Gewebe zeigt: Phosphorylation basischer Proteine (Histon) in Serin- und Threoninresten, Magnesiumabhängigkeit und Stimulation durch Adenosin 3′,5′-monophosphat. Dieses Enzym könnte ein wichtiges Bindeglied zwischen der intracellulären c-AMP-Konzentration und der Plättchen-Funktion darstellen.
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Kaulen, H.D., Gross, R. Demonstration of adenosin 3′,5′-monophosphate dependent protein-phosphokinase in human platelets. Klin Wochenschr 50, 1114–1115 (1972). https://doi.org/10.1007/BF01486857
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DOI: https://doi.org/10.1007/BF01486857