Summary
In vitro experiments with human semen showed a significant increase of quantitative and qualitative sperm motility after addition of kallikrein at concentrations of 1 KU/ml. Stimulation of sperm motility was further increased and extended by addition of human serum as a source of kininogen. Kinins added directly also showed enhancement of sperm motility. In contrast, carboxypeptidase B, a kininase, significantly reduced sperm motility. The physiological and therapeutical aspects of these results are discussed.
Zusammenfassung
In vitro-Versuche mit Humansperma unter Zusatz von Kallikrein in Konzentrationen von 1 KE/ml ergaben einen signifikanten Anstieg der quantitativen und qualitativen Motilität der Spermatozoen. Durch Zusatz von Serum als Kininogenquelle konnte dieser Effekt noch gesteigert und verlängert werden. Die Spermatozoenmotilität konnte auch durch den direkten Zusatz von Kininen stimuliert werden. Im Gegensatz dazu führte Carboxypeptidase B, eine Kininase, zu einer signifikanten Motilitätseinschränkung. Die physiologischen und therapeutischen Aspekte dieser Befunde werden diskutiert.
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Schill, W.B., Haberland, G.L. Wirkungen von verschiedenen Komponenten des Kallikrein-Kinin-Systems auf die Spermatozoen-Motilität in vitro. Klin Wochenschr 53, 73–79 (1975). https://doi.org/10.1007/BF01482712
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DOI: https://doi.org/10.1007/BF01482712