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Klinische und in vitro-Untersuchungen zur therapeutischen Breite von Acetylsalicylsäure zur Thromboseprophylaxe

Clinical and in-vitro studies of the therapeutical range of acetylsalicylic-acid to prevent deep vein thrombosis

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Summary

In three consecutive studies, acetylsalicyliclysine using the dosages 0.9 g/48 h, 1.8 g/24 h and 3.6 g/24 h, was examined in order to see its effect in preventing deep vein thrombosis (DVT) after elective hip joint surgery. DVT was diagnosed by the 125-I-fibrinogen-test.

No reduction of postoperative DVT was found under any of the administered AS-lysine dosages.

The collagen-induced platelet aggregation was significantly decreased in all three groups. However, under the low AS-lysine dosages, aggregation was less inhibited with the incidence of DVT than without DVT. In the group with the 3.6 g-dosage, aggregation was maximally inhibited, without any significant difference related to the occurrence of DVT.

The results reveal no therapeutic range of AS-lysine to prevent postoperative venous thrombosis.

Zusammenfassung

Acetylsalicyl-lysin wurde in den Dosierungen 0,9 g/48 h, 1,8 g/24 h und 3,6 g/24 h in drei nacheinander folgenden Studien zur Thromboseprophylaxe bei Hüftgelenksoperationen anhand des Radio-Fibrinogen-Tests untersucht. Mit den drei AS-lysin-Dosierungen wurde keine Verminderung von Thrombosen (TVT) gefunden.

Die Kollagen-induzierte Thrombozytenaggregation war in allen drei Gruppen signifikant gesenkt. Unter den niedrigen AS-lysin-Dosen war die Aggregation beim Auftreten einer TVT weniger stark gehemmt als beim Ausbleiben einer TVT. Bei der 3,6 g-Dosis war die Aggregation maximal ohne signifikante Unterschiede vom Thrombosevorkommen gehemmt.

Die Befunde ergeben keinen therapeutischen Bereich für die Acetylsalicylsäure zur Verhütung venöser Thrombosen.

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Literatur

  1. Al-Monhiri, H., Marcus, A.J., Spaet, T.H.: On the mechanism of platelet function inhibition by acetylsalicylic acid. Proc. Soc. exper. Biol. Med.133, 632 (1970)

    Google Scholar 

  2. Bockslaff, H., Barthels, M., Stolle, E., Trentz, O., Wuppermann, Th., Zech, G.: Frühdiagnose von Beinvenenthrombosen mit dem Radiofibrinogentest bei Patienten mit alloplastischem Hüftgelenkersatz. Münch. med. Wschr.116, 1397 (1974)

    Google Scholar 

  3. Born, G.V.R.: Quantitative investigation into aggregation of blood platelets. J. Physiol.162, 67 (1962)

    Google Scholar 

  4. Breddin, K., Scharrer, I., Schepping, M.: Die Hemmung der Plättchenaggregation mit Azetylsalizylsäure. Münch. med. Wschr.113, 1284 (1971)

    Google Scholar 

  5. British Medical Research Council: Effect of aspirin on postoperative venous thrombosis. Report of the Steering Committee. LancetII, 441 (1972)

    Google Scholar 

  6. Dechavanne, M., Ville, D., Viala, J.J., Kher, A., Faivre, J., Pusset, M.B., Dejour, H.: Controlled trial of platelet antiaggregating agents and subcutaneous heparin in prevention of postoperative deep vein thrombosis in high risk patients. Haemostasis4, 94 (1975)

    Google Scholar 

  7. Encke, A., Stock, C., Dumke, H.O.: Doppelblindstudie zur postoperativen Thromboseprophylaxe mit Dipyridamol/Acetylsalicylsäure. Chirurg47, 670 (1976)

    Google Scholar 

  8. Evans, G., Packham, M.A., Nishizawa, E.E., Mustard, J.F., Murphy, E.A.: The effect of acetylsalicylic acid on platelet function. J. Exp. Med.128, 877 (1968)

    Google Scholar 

  9. Farbiszewski, R., Niewiarowski, S., Worowski, K., Lipinski, B.: Release of platelet factor 4 in vivo during intravascular coagulation and in thrombotic states. Thrombos. Diathes. haemorrh.19, 578 (1968)

    Google Scholar 

  10. Hamberg, M., Svenson, J., Wakabayashi, T., Samuelsson, B.: Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc. Nat. Acad. Sci.71, 345 (1974)

    Google Scholar 

  11. Harris, W.H., Salzman, E.W., Athansoulis, C., Waltman, A.C., Baum, S., DeSanctis, R.W.: Comparison of warfarin, low-molecular-weight dextran, aspirin, and subcutanous heparin in prevention of venous thromboembolism following total hip replacement. J. Bone and Joint Surg.56, 1552 (1974)

    Google Scholar 

  12. Heinrich, H., Róka, L.: Methode zur Bestimmung der Thrombocytenaggregation. Klin. Wschr.48, 235 (1970)

    Google Scholar 

  13. Hey, D., Heinrich, D., Burckhardt, H.: Zur Prophylaxe thromboembolischer Komplikationen bei großen Hüftgelenkseingriffen. Münch. med. Wschr.115, 1967 (1973)

    Google Scholar 

  14. Jennings, J.J., Harris, W.H., Sarmiento, A.: A clinical evaluation of aspirin prophylaxis of thromboembolic disease after total hip arthoplasty. J. Bone Joint Surg.58-A, 926 (1976)

    Google Scholar 

  15. Kakkar, V.V., Nicolaides, A.N., Renney, J.T.G., Friend, J.R., Clarke, M.B.: 125 J-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. LancetI, 540 (1970)

    Google Scholar 

  16. Loew, D., Wellmer, H.-K., Baer, U., Merguet, H., Rumpf, P., Persch, W.F., Marx, F.J., von Bary, S.M.: Postoperative Thromboembolie-Prophylaxe mit Acetylsalicylsäure. Dtsch. med. Wschr.99, 565 (1974)

    Google Scholar 

  17. Matt, E.M., Gruber, U.F.: Prophylaxe postoperativer thromboembolischer Komplikationen mit subkutan verabreichten kleinen Heparin-Dosen. Fortschr. Med.95, 669 (1977)

    Google Scholar 

  18. Meng, K.: Tierexperimentelle Thrombose und Behandlung mit Acetylsalicylsäure. Med. Welt27(N.F.), 1359 (1976)

    Google Scholar 

  19. Morris, C.D.W.: Observations on the effect of glass beads on platelet aggregation and its relation to platelet stickiness. Thrombos. Diathes. haemorrh.20, 345 (1968)

    Google Scholar 

  20. Morris, G.K., Mitchell, J.R.A.: Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen. Brit. med. J.1, 535 (1977)

    Google Scholar 

  21. Negus, D., Pinto, D.J., La Quesne, L.P., Brown, N., Chapman, M.: 125-I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography. Brit. J. Surg.55, 835 (1968)

    Google Scholar 

  22. Nicolaides, A.N., Irving, D.: Clinical factors and the risk of deep venous thrombosis. In: Thromboembolism, Aetiology, Advances in Prevention and Management. Hrsg.: A.N. Nicolaides, Medical and Technical Publishing Co. Ltd. (1975)

  23. O'Brien, J.R.: Effects of salicylates on human platelets. LancetI, 779 (1968)

    Google Scholar 

  24. O'Brien, J.R.: Detection of thrombosis with iodine-125 fibrinogen. LancetII, 396 (1970)

    Google Scholar 

  25. Pinto, D.J.: Controlled trial of an anticoagulant (warfarin sodium) in the prevention of venous thrombosis following hip surgery. Brit. J. Surg.57, 349 (1970)

    Google Scholar 

  26. Quick, A.J.: Salicylates and bleeding: The aspirin tolerance test. Amer. J. Med. Sci.252, 265 (1966)

    Google Scholar 

  27. Renny, J.T.G., O'Sullivan, E.F., Burke, P.F.: Prevention of postoperative deep vein thrombosis with dipyridamol and aspirin. Brit. med. J.1, 992 (1976)

    Google Scholar 

  28. Salzman, E.W., Harris, W.H., DeSanctis, R.W.: Reduction in venous thromboembolism by agents affecting platelet function. N. Engl. J. Med.284, 1287 (1971)

    Google Scholar 

  29. Schöndorf, T.H., Hey, D.: Wirksamkeit von subkutan verabreichtem Heparin zur Thromboseprophylaxe bei großen Hüftgelenkseingriffen. Kontrollierte Studie. Dtsch. med. Wschr.100, 2014 (1975)

    Google Scholar 

  30. Schöndorf, T.H., Hey, D.: Gerinnungsanalytische Untersuchungen zur Thrombogenese bei großen Hüftgelenksoperationen. Inn. Med.3, 365 (1976)

    Google Scholar 

  31. Schöndorf, T.H., Hey, D.: Combined administration of low dose heparin and aspirin as prophylaxis of deep vein thrombosis after hip joint surgery. Haemostasis5, 250 (1976)

    Google Scholar 

  32. Schöndorf, T.H., Hey, D.: Aussagekraft von Kontrollmethoden zur postoperativen Überwachung einer Acetylsalicyl-lysin-und Heparinmedikation. Münch. med. Wschr.119, 119 (1977)

    Google Scholar 

  33. Schöndorf, T.H., Weber, U., Lasch, H.G.: Niedrig dosiertes Heparin und Acetylsalicylsäure nach elektiven Operationen am Hüftgelenk. Dtsch. med. Wschr.102, 1314 (1977)

    Google Scholar 

  34. Schöndorf, T.H.: Klinische und gerinnungsphysiologische Untersuchungen zur Thromboseprophylaxe bei großen Hüftgelenksoperationen. Habilitationsschrift, Gießen (1977)

    Google Scholar 

  35. Schöndorf, T.H., Hey, D.: Modified “low-dose” heparin prophylaxe to reduce thrombosis after hip joint operations. Thrombos. Res.12, 153 (1978)

    Google Scholar 

  36. Smith, J.B., Willis, A.L.: Aspirin selectively inhibits prostaglandin production in human platelets. Nature New Biol.231, 235 (1971)

    Google Scholar 

  37. Soreff, J., Johnsson, H., Diener, L., Göransson, L.: Acetylsalicylic acid in a trial to diminish thromboembolic complications after elective hip surgery. Acta orthop. Scand.46, 246 (1975)

    Google Scholar 

  38. Weber, W., Wolff, V., Bromig, G.: Postoperative Thromboembolie-Prophylaxe mit Colfarit®. Therapeut. Bericht43, 229 (1971)

    Google Scholar 

  39. Weiss, H.J., Aledort, L.M., Kochwa, S.: The effect of salicylates on the hemostatic properties of platelet in man. J. Clin. Invest.47, 2169 (1968)

    Google Scholar 

  40. Wood, E.H., Prentice, C.R.M., McGrouther, D.A., Sinclair, J., McNicol, G.P.: Trial of aspirin and RA 233 in prevention of post-operative deep vein thrombosis. Thrombos. Diath. haemorrh.30, 18 (1973)

    Google Scholar 

  41. Youssef, A.H., Barkhan, P.: Inhibition by aspirin of release antiheparin activity from human platelets. Brit. med. J.3, 394 (1969)

    Google Scholar 

  42. Zekert, F., Kohn, P., Vormittag, E., Poigenfürst, J., Thien, M.: Thromboembolieprophylaxe mit Acetylsalicylsäure bei Operationen wegen hüftgelenksnaher Frakturen. Mschr. Unfallheilk.77, 97 (1974)

    Google Scholar 

  43. Zucker, M.B., Peterson, J.: Inhibition of adenosin diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion. Proc. Soc. exp. Biol.127, 547 (1968)

    Google Scholar 

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Authors and Affiliations

  1. Zentrum für Innere Medizin Justus Liebig-Universität Giessen, Germany

    T. H. Schöndorf, D. Hey & H. G. Lasch

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  1. T. H. Schöndorf
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  2. D. Hey
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  3. H. G. Lasch
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Schöndorf, T.H., Hey, D. & Lasch, H.G. Klinische und in vitro-Untersuchungen zur therapeutischen Breite von Acetylsalicylsäure zur Thromboseprophylaxe. Klin Wochenschr 56, 1113–1118 (1978). https://doi.org/10.1007/BF01477133

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