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Oxidativer Metabolismus von Phagozyten: Physikochemische Grundlagen und klinische Relevanz

Oxidative metabolism of phagocytes: Physicochemical events and clinical relevance

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Summary

The microbicidal activity of phagocytes is primarily dependent upon two intracellular processes: degranulation and respiratory burst. The latter one is associated with a partial reduction of molecular oxygen leading to the production of highly reactive oxydizing agents with microbicidal activity. Since an efficiant intracellular antimicrobial function of phagocytes is mainly based on the intracellular process of fusion of lysosomes with the phagocytic vesicles and the production of highly reactive oxygen radicales, disturbances of both these events will cause increased susceptibility against microorganisms and in most of the cases severe infections.

Zusammenfassung

Die mikrobizide Aktivität von Phagozyten beruht primär auf zwei intracellulären Prozessen: Degranulation und Stimulierung des cellulären oxidativen Metabolismus. Der während der Phagozytose aktivierte oxidative Metabolismus ist mit einer partiellen Reduktion des molekularen Sauerstoffs verbunden und führt zur Bildung hochreaktiver Oxidationsmittel mit mikrobizider Wirkung. Da eine effiziente intracelluläre antimikrobielle Funktion der Phagozyten sowohl vom intracellulären Vorgang der Verschmelzung der Lysosomen mit den phagozytischen Vakuolen als auch von der Bildung von Sauerstoffradikalen abhängig ist, führen Störungen der beiden Prozesse zu einer erhöhten Infektanfälligkeit mit zum Teil ernster klinischer Symptomatik.

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  1. Dept. f. Innere Medizin, Universitätsspital, Rämistr. 100, CH-8091, Zürich, Schweiz

    L. H. Block, R. Lüthy &  W. Siegenthaler

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  1. L. H. Block
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  2. R. Lüthy
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Block, L.H., Lüthy, R. & Siegenthaler, W. Oxidativer Metabolismus von Phagozyten: Physikochemische Grundlagen und klinische Relevanz. Klin Wochenschr 58, 1271–1281 (1980). https://doi.org/10.1007/BF01478136

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