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Receptor dysfunctions in human disease

Rezeptordysfunktionen und ihre klinischen Manifestationen

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Summary

The characterization of binding parameters of hormones and drugs to specific receptors at various human cell types have introduced an interesting approach for the evaluation of pathogenic mechanisms involved in endocrine and metabolic disorders. The dysregulation of cellular receptors in those disease include changes in receptor number, changes in binding affinity and production of antibodies against receptor molecules. It can be concluded from these observations that altered receptor physiology may be of important value for abnormalities in cellular recognition and control mechanisms which can be observed in neoplastic, inflammatory, immune and developmental diseases.

Zusammenfassung

Die Charakterisierung der Bindungsparameter von Hormonen und Pharmaka an spezifischen Rezeptoren humaner Zelltypen haben zur Evaluierung von pathologischen Mechanismen geführt, die in die Entstehung von endokrinologischen und metabolischen Erkrankungen involviert sind. Die Fehlregulation zellulärer Rezeptoren bei solchen Erkrankungen äußern sich in Veränderungen der Rezeptorzahl, der Bindungsaffinität sowie in der Bildung von Antikörpern gegen Rezeptormoleküle. Aus der Darstellung dieser Vorgänge kann geschlossen werden, daß eine gestörte Rezeptorphysiologie möglicherweise für die Entgleisung zellulärer Erkennungsvorgänge und Kontrollmechanismen verantwortlich ist, die u.a. bei Neoplasien, Entzündungsreaktionen, Immunerkrankungen und Entwicklungsstörungen beobachtet werden.

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Authors and Affiliations

  1. Department für Innere Medizin, Universitätsspital Zürich, Switzerland

    L. H. Block, W. Tenschert, R. Locher, W. Siegenthaler & W. Vetter

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  1. L. H. Block
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  2. W. Tenschert
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  3. R. Locher
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  4. W. Siegenthaler
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  5. W. Vetter
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Block, L.H., Tenschert, W., Locher, R. et al. Receptor dysfunctions in human disease. Klin Wochenschr 59, 355–363 (1981). https://doi.org/10.1007/BF01698513

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