Summary
Cimetidine, a histamine H2-receptor-antagonist, was administered either as a single 400 mg dose perorally 10–12 h before operation, or in a 400 mg dose perorally 10–12 h before operation plus 200 mg intravenously 1–2 h before operation, in 63 patients awaiting general elective surgery. Distribution of patients showed a significantly greater number of patients with a pH >2.5 in cimetidine groups, as compared to controls only, if the whole time of anaesthesia is taken into consideration. Between the two cimetidine regimens there was no statistically significant difference. These findings suggest that cimetidine is not necessary as a routine pre-operative medication in general elective surgery.
Zusammenfassung
Der Histamin H2-Antagonist Cimetidin wurde 63 Patienten vor elektiven allgemeinchirurgischen Eingriffen in 2 verschiedenen Regimes verabreicht: Eine Gruppe erhielt 400 mg per os 10–12 h vor der Operation, eine zweite 400 mg per os 10–12 h plus 200 mg intravenös 1–2 h vor Operationsbeginn.
Es wurde eine signifikant größere Anzahl von Patienten mit einem pH >2,5 in den Cimetidin-behandelten Gruppen nur gefunden, wenn man den ganzen Zeitraum der Narkose mit berücksichtigte.
Nach diesen Ergebnissen wird Cimetidin bei elektiven Eingriffen als nicht notwendige Routineprämedikation erachtet.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Coombs DW, Hooper D, Colton T (1979) Pre-anesthetic cimetidine alteration of gastric fluid volume and pH. Anesth Analg 58:183–188
Coombs DW, Hooper D, Colton T (1979) Acid-aspiration prophylaxis by use of preoperative oral administration of cimetidine. Anesthesiology 51:352–356
Dobb G, Jordan J, Williams JG (1979) Cimetidine in the prevention of the pulmonary acid aspiration (Mendelson's) syndrome. Br J Anaesthesia 51:967–970
Husemeyer RP, Davenport HT, Rajasekaran T (1978) Cimetidine as a single oral dose for prophylaxis against Mendelson's syndrome. Anaesthesia 33:775–778
Husemeyer RP, Davenport HT (1980) Prophylaxis for Mendelson's syndrome before elective caesarean section. A comparison of cimetidine and magnesium trisilicate mixture regimens. Br J Obstet Gynaecol 87:565–570
Keating PJ, Black JF, Watson DW (1978) Effects of glycopyrrolate and cimetidine on gastric volume and acidity in patients awaiting surgery. Br J Anaesthesia 50:1247–1250
Kirkegaard P, Sorensen O, Kirkegaard P (1980) Cimetidine in the prevention of acid aspiration during anesthesia. Acta Anaesth Scand 24:58–60
Maliniak K, Vakil H (1979) Pre-anesthetic cimetidine and gastric pH. Anesth Analg 58:309–313
Roberts RB, Shirley MA (1974) Reducing the risk of acid aspiration during cesarean section. Anesth Analg 53:859–868
Stoelting RK (1978) Gastric fluid pH in patients receiving cimetidine. Anesth Analg 57:675–677
Strain JD, Moore EE, Markovchick VJ, van Duzer-Moore S (1981) Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients. J of Trauma 21:49–51
Taylor G (1975) Acid pulmonary aspiration syndrome after antacids. Br J Anaesth 47:615–616
Toung T, Cameron JL (1980) Cimetidine as a preoperative medication to reduce the complications of aspiration of gastric contents. Surgery 87:205–208
Weber L, Hirshman CA (1979) Cimetidine for prophylaxis of aspiration pneumonitis: Comparison of intramuscular and oral dosage schedules. Anesth Analg 58:426–427
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Feifel, G., Finke, U., Schmitz, E.R. et al. Prevention of acid aspiration by H2-receptor antagonists. Klin Wochenschr 60, 1060–1062 (1982). https://doi.org/10.1007/BF01716972
Issue Date:
DOI: https://doi.org/10.1007/BF01716972