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Behandlung mit Mexiletin

Clinical and pharmacokinetik studies on treatment with mexiletine

Klinische und pharmakokinetische Untersuchungen

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Summary

Pharmacokinetics of the antiarrhythmic agent mexiletine were found to be highly variable. Ineffective or toxic doses can be avoided by monitoring mexiletine concentrations in patients plasma. However, the success of antiarrhythmic therapy is mainly determined by the severety of the underlying disease. Therefore, the efficacy of treatment with mexiletine should be controlled by Holter monitoring.

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Authors and Affiliations

  1. Medizinische Klinik der Universität Gießen, Germany

    H. Breithaupt & A. Schmidt

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  1. H. Breithaupt
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  2. A. Schmidt
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Herrn Prof. Dr. G. Schütterle zum 60. Geburtstag gewidmet

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Breithaupt, H., Schmidt, A. Behandlung mit Mexiletin. Klin Wochenschr 66, 475–481 (1988). https://doi.org/10.1007/BF01876168

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  • DOI: https://doi.org/10.1007/BF01876168

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