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Vermindertes Plasmacarnitin bei Typ-I Diabetes mellitus

Decreased plasma carnitine in type-I Diabetes mellitus

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Summary

Realizing the importance of carnitine for the lipid and carbohydrate metabolism and the possible role for glucose utilization and myocardial function carnitine concentrations in type I and type II diabetic patients in plasma, erythrocytes and 24 h urine were determined. The plasma levels of carnitine were significantly diminished in type I diabetic patients compared to controls, while carnitine concentrations in erythrocytes and 24 h urine did not differ from controls. Plasma carnitine levels did not change significantly during the diurnial profile. No correlation between HbA1c and carnitine levels was observed in the diabetic patients.

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Literatur

  1. Bahl J, Bressler R (1987) The Pharmacology of Carnitine. Ann Rev Pharmacol Toxicol 27:257–277

    Google Scholar 

  2. Böhles H (1985) Carnitin-Biochemie und Klinik. Infusionstherapie 12:60–69

    Google Scholar 

  3. Böhmer T, Norum KR, Bremer J (1966) The relative amounts of long-chain acylcarnitine, acetylcarnitine and free carnitine in organs of rats in different nutritional states and with alloxan diabetes. Biochim. Biophys Acta 125:244–251

    Google Scholar 

  4. Böhmer T, Rydning A, Solberg HE (1974) Carnitine levels in human serum in health and disease. Clin Chim Acta 57:55–61

    Google Scholar 

  5. Broderick TL, Poirier P (1989) Effect of exogenous insulin on plasma free carnitine levels during exercise in normal man. Can J Physiol Pharmacol 67:1598–1601

    Google Scholar 

  6. Cederblad G, Lindstedt S (1972) A method for the determination of carnitine in the picomole range. Clin Chim Acta 37:235–243

    Google Scholar 

  7. Cederblad G, Lundholm K, Schersten T (1977) Carnitine concentration in skeletal muscle tissue from patients with diabetes mellitus. Acta Med Scand 202:305–306

    Google Scholar 

  8. Cederblad G, Hermansson G, Ludvigsson J (1982) Plasma and urine carnitine in children with diabetes mellitus. Clin Chim Acta 125:207–217

    Google Scholar 

  9. Digiesi V, Palchetti R, Cantini F (1989) Utilita della terapia con L-carnitina nell ipertensione arteriosa essenziale con diabete mellito tipo II. Min Med 80:227–231

    Google Scholar 

  10. Duan J, Karmazyn M (1989) Effect of D,L-carnitine on the response of the isolated heart of the rat to ischaemia and reperfusion: Relation to mitochondrial function. Br J Pharmacol 98:1319–1327

    Google Scholar 

  11. Editorial (1990) Carnitine deficiency. Lancet 1:631–633

  12. Ferranini E, Buzzigoli G, Bevilaqua S, Boni C, Del Chiaro D, Oleggini M, Brandi L, Maccari F (1988) Interaction of carnitine with insulin-stimulated glucose metabolism in humans. Am J Physiol 255:E946-E952

    Google Scholar 

  13. Friedewald WT, Levy RI, Friedrickson TS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preperative ultracentrifuge. Clin Chem 18:499

    Google Scholar 

  14. Genuth SM, Hoppel CL (1979) Plasma and urine carnitine in diabetic ketosis. Diabetes 28:1083–1087

    Google Scholar 

  15. Holme E, Jacobson CE, Nordin I, Greter J, Lindstedt S, Kristiansson B (1989) Carnitine Deficiency induced by Pivampicillin and Pivmecillinam therapy. Lancet 2:469–472

    Google Scholar 

  16. Ino T, Sherwood WG, Cutz E, Benson LE, Rose V, Freedom RM (1988) Dilated cardiomyopathy with neutropenia, short stature and abnormal carnitine metabolism. Pediatrics 113:511–514

    Google Scholar 

  17. Khoss AE, Steger H, Legenstein E, Proll E, Salzer-Muhar U, Schlemmer M, Balzar E, Wimmer M (1989) L-Carnitintherapie und Myokardfunktion bei chronisch hämodialysierten Kindern. Wien Klin Wochenschr 101:17–20

    Google Scholar 

  18. Kostner GM, Avogaro P, Bittolo Bon G, Cazzolato G (1979) The determination of high densitiy lipoproteins in the lipoprotein laboratory-screening methods compared. Clin Chem 25:939

    Google Scholar 

  19. Laurell S, Tibbling G (1967) Colorimetric micro-determination of free fatty acids in plasma. Clin Chim Acta 16:57–62

    Google Scholar 

  20. Lohninger A, Kaiser E, Legenstein E, Staniek H (1987) Carnitine, metabolism and function. In: Kaiser E, Lohninger A (Eds) Carnitine — its role in lung and heart disorders. Karger, Basel New York, pp 1–25

    Google Scholar 

  21. Maccari F, Arseni A, Chiodi P, Ramacci MT, Angelucci L, Hulsmann WC (1987) L-carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats. Lipids 22:1005–1008

    Google Scholar 

  22. Maebashi M, Kawamura N, Sato M, Imamura A, Yoshinaga K, Suzuki M (1977) Urinary excretion of carnitine and serum concentrations of carnitine and lipids in patients with hypofunctional endocrine diseases: Involvement of adrenocorticoid and thyroid hormones in ACTH-induced augmentation of carnitine and lipid metabolism. Metabolism 26:357–361

    Google Scholar 

  23. Maebashi M, Kawamura N, Sato M, Imamura A, Yoshinaga K (1978) Lipid lowering effect of carnitine in patients with Type-IV hyperlipoproteinämia. Lancet:805–807

  24. McGarry JD, Mannaerts GP, Foster DW (1977) A possible role for Malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest 60:265–270

    Google Scholar 

  25. Nestruck CA, Pande SV, Davignon J (1984) Plasma carnitine and lipid-lowering drugs. Atherosclerosis 55:353–356

    Google Scholar 

  26. Pearson D, Tubbs PK (1967) Carnitine and its derivates in rat tissues. Biochem J 105:953–963

    Google Scholar 

  27. Randle OP J, Garland PB, Harles CN, Newsholme EA (1963) The glucose fatty-acid cycle. Lancet 1:785–789

    Google Scholar 

  28. Rebouche CJ, Bosch P, Chenard CA, Schabold KJ, Nelson SE (1989) Utilization of dietary precursors for carnitine synthesis in human adults. J Nutr 119:1907–1913

    Google Scholar 

  29. Richter V, Rassoul F, Schulz G, Sittner WD, Seim H, Löster H, Rotzsch W (1987) Carnitine and experimental carbohydrate-induced hyperlipoproteinemia. Arch Int Pharmacodyn 290:138–144

    Google Scholar 

  30. Rodrigues B, Xiang H, McNeill JH (1988) Effect of L-carnitine treatment on lipid metabolism and cardiac performance in chronically diabetic rats. Diabetes 37:1358–1364

    Google Scholar 

  31. Rössle C, Carpentier A, Richelle M, Dahlan W, D'Attellis NP, Fürst P, Elwyn DH (1990) Medium-chain triglycerides induce alterations in carnitine metabolism. Am J Physiol 258:E944-E947

    Google Scholar 

  32. Schernthaner G, Kostner GM, Dieplinger H, Prager R, Mühlhauser I (1983) Apolipoproteins (A-I, A-II, B), Lp (a) Lipoprotein and Lecithin: Cholesterol Acyltransferase Activity in Diabetes Mellitus. Atherosclerosis 49:277–293

    Google Scholar 

  33. Schmidt-Sommerfeld E, Penn D (1986) Carnitinmangel. Monatsschr Kinderheilkd 134:224–231

    Google Scholar 

  34. Scholte HR, Luyt-Howen IEM, Vaandrager-Verduin MHM (1987) The role of carnitine system in myocardial fatty acid oxidation: carnitine deficiency, failing mitochondria and cardiomyopathy. Basic Res Cardiol [Suppl 1]:63–73

    Google Scholar 

  35. Schwenk F, Hale DE, Haymond MW (1988) Decreased Fasting Free Fatty Acids with L-Carnitine in Children with Carnitine Deficiency. Pediatr Res 23:491–494

    Google Scholar 

  36. Treem WR, Stanley CA, Finegold DN, Hale DE, Coates PM (1988) Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle and fibroblasts. N Engl J Med 319:1331–1335

    Google Scholar 

  37. Vary TC, Neely JR (1982) A mechanism for reduced myocardial carnitine levels in diabetic animals. Am J Physiol 243:H154–158

    Google Scholar 

  38. Winter SC, Simon M, Zorn ME, Szabo-Aczel S, Vance W, O'Hara T, Higashi L (1989) Relative carnitine insufficiency in children with Type I Diabetes Mellitus. Am J Dis Child 143:1337–1339

    Google Scholar 

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Authors and Affiliations

  1. Institut für Medizinische Chemie und II. Medizinische Klinik der Universität Wien, Österreich

    P. Pregant, G. Schernthaner, E. Legenstein, L. Lienhart, S. Bruck, Ch. Schnack & E. Kaiser

  2. I. Medizinische Abteilung der Krankenanstalt Rudolfstiftung, Wien

    P. Pregant, G. Schernthaner, E. Legenstein, L. Lienhart, S. Bruck, Ch. Schnack & E. Kaiser

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  1. P. Pregant
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  2. G. Schernthaner
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  3. E. Legenstein
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  4. L. Lienhart
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  6. Ch. Schnack
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  7. E. Kaiser
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Pregant, P., Schernthaner, G., Legenstein, E. et al. Vermindertes Plasmacarnitin bei Typ-I Diabetes mellitus. Klin Wochenschr 69, 511–516 (1991). https://doi.org/10.1007/BF01649287

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  • DOI: https://doi.org/10.1007/BF01649287

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