Summary
Cardiac function was investigated by echocardiography in 24 short-term Type 1 diabetic patients with a mean diabetes duration of 7 years (range 4–14 years) during conditions of ordinary metabolic control. Compared to 24 age and sex matched normal control subjects, measurements of myocardial contractility as left ventricular fractional shortening and mean circumferential shortening velocity were increased by 12% and 20% respectively. Another 8 Type 1 diabetic patients were examined during conditions of poor (hyperglycaemia and ketosis) and good metabolic control. Following improved glycaemic control, left ventricular fractional shortening and mean circumferential shortening velocity decreased by 16% and 24% respectively. Our findings show that short-term Type 1 diabetes is associated with increased myocardial contractility. Furthermore, this condition is related to the state of metabolic control.
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References
Mogensen CE (1972) Kidney function and glomeralar permeability to macromolecules in juvenile diabetes. Dan Med Bul 19 (Suppl3): 1–40
Christiansen JS, Gammelgaard J, Frandsen M, Parving H-H (1981) Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin dependent diabetics. Diabetologia 20: 451–456
Puig JG, Antón FM, Grande C (1981) Relation of kidney size to kidney function in early insulin-dependent diabetes. Diabetologia 21: 363–367
Nyberg G, Granerus G, Aurell M (1982) Renal extraction ratios for Cr-EDTA, PAH and glucose in early insulin-dependent diabetic patients. Kidney Int 21: 706–708
Christiansen JS, Gammelgaard J, Tronier B, Svendsen PA, Parving H-H (1982) Kidney function and size in diabetics before and during initial insulin treatment. Kidney Int 21: 683–688
Kohner EM, Hamilton AM, Saunders SJ, Sutcliffe BA, Bulpitt CJ (1975) The retinal blood flow and diabetes. Diabetologia 11: 27–33
Dandona P, Wollard ML, James IM, Newburry P, Beckett AG (1979) Instability of cerebral blood flow in insulin-dependent diabetics. Lancet 2: 1203–1205
Gundersen HJG (1974) Peripheral blood-flow and metabolic control in juvenile diabetes. Diabetologia 10: 225–231
Feigenbaum H (1981) Echocardiography, 3rd Lea and Fibiger, Philadelphia, pp 119–221
Teichholz LE, Kreulen T, Herman MV, Gorlin R (1976) Problems in echocardiographic volume determinations: echocardiographic-angiographic correllations in the presence or absence of asynergy. Am J Cardiol 37: 7–11
Ledet T (1976) Diabetic cardiopathy. Quantitative histological studies of the heart from young juvenile diabetics. Acta Pathol Microbiol Scand 84: 421–428
Shapiro LM, Leatherdale BA, Mackinnon J, Fletcher RF (1981) Left ventricular function in diabetes mellitus. Br Heart J 45: 129–132
Sultan Ahmed S, Jaferi GA, Narang RM, Regan TJ (1975) Preclinical abnormality of left ventricular function in diabetes mellitus. Am Heart J 89: 153–158
Sanderson JE, Brown DJ, Rivellese A, Kohner E (1978) Diabetic cardiopathy? An echocardiographic study of young diabetics. Br Med J 1: 404–407
Seneviratne BIB (1977) Diabetic cardiopathy: the preclinical phase. Br Med J 1: 1444–1446
Lababidi ZA, Goldstein DE (1983) High prevalence of echocardiographic abnormalities in diabetic youths. Diabetes Care 6: 18–22
Christensen NJ (1974) Plasma norepinephrine and epinephrine in untreated diabetics during fasting and after insulin administration. Diabetes 25 (Suppl 2): 903–908
Ludbrook P, Karliner JS, Peterson K, Leopold G, O'Rourke RA (1973) Comparison of ultrasound and cineangiographic measurements of left ventricular performance in patients with and without wall motion abnormalities. Br Heart J 35: 1026–1032
Thuesen L, Christiansen JS, Jensen NF (1984) Reduced cardiac output following improved metabolic control in Type 1 (insulin-dependent) diabetic patients. Diabetologia 27: 338A
Mathiesen ER, Hilsted J, Feldt-Rasmussen B, Bonde-Petersen F, Christensen NJ, Parving H-H (1985) Effect of metabolic control on haemodynamics in short-term insulin-dependent diabetic patients. Diabetes (in press)
Soeldner JS, Christacopoulus PD, Gleason RE (1976) Mean retinal circulation time as determined by flourescein angiography in normal, prediabetic and chemical-diabetic subjects. Diabetes 25 (Suppl 2): 903–908
Häggendal E, Steen B, Svanberg A (1970) Blood-flow in subcutanous tissue in patients with diabetes mellitus. Acta Med Scand 187: 49–53
Parving H-H, Viberti GC, Keen H, Christiansen JS, Lassen NA (1983) Hemodynamic factors in the genesis of diabetic microangiopathy. Metabolism 32: 943–949
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Thuesen, L., Sandahl Christiansen, J., Falstie-Jensen, N. et al. Increased myocardial contractility in short-term Type 1 diabetic patients: an echocardiographic study. Diabetologia 28, 822–826 (1985). https://doi.org/10.1007/BF00291071
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DOI: https://doi.org/10.1007/BF00291071