Abstract
Objective
to investigate the epidemiology of infection byPseudomonas aeruginosa in patients with ventilator-associated pneumonia (VAP).
Design
prospective clinical study.
Setting
a medical-surgical ICU in a university hospital.
Patients
we followed-up 568 mechanically ventilated patients and 83 episodes of VAP with etiologic diagnosis in 72 patients were retained for analysis.
Results
Ps. aeruginosa was isolated in 22 (26.5%) episodes in 18 patients. Of these episodes 7 were directly responsible for death. Using logistic regression analysis, the risk of VAP due toPs. aeruginosa was increased in patients with chronic obstructive pulmonary disease (relative risk (RR)=29.9, 95% confidence interval (CI)=4.86-184.53), a mechanical ventilation period longer than 8 days (RR=8.1, 95% CI=1.01-65.40) and prior use of antibiotics (RR=5.5, 95% CI=0.88-35.01).
Conclusions
patients with VAP and these factors have a greater risk of infection byPs. aeruginosa and empirical therapy for these episodes should include anti-pseudomonal activity until etiologic diagnosis is established.
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Rello, J., Ausina, V., Ricart, M. et al. Risk factors for infection byPseudomonas aeruginosa in patients with ventilator-associated pneumonia. Intensive Care Med 20, 193–198 (1994). https://doi.org/10.1007/BF01704699
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DOI: https://doi.org/10.1007/BF01704699