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Cadmium accumulation in organs and mortality during a continued oral uptake

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Abstract

Paste-form food containing cadmium (10 ppm or 50 ppm) was administered to rats (Wistar strain, ♀) in a long-term study of cadmium content in the organs and mortality rate.

The following results were obtained:

  1. (i)

    Cadmium intake (10 ppm or 50 ppm) led to an immediate reduction of food consumption and growth. As a result of 41 weeks of cadmium intake, the cadmium accumulation rate in the kidney and liver of the 10 ppm group (0.47%) did not differ from that of the 50 ppm group (0.53%). However, the distribution rate of cadmium to the kidney or liver depended on its concentration. With a 10 ppm intake, the kidney contained the same amount of cadmium as the liver, but with a 50 ppm intake it contained only one fourth of that in the liver.

  2. (ii)

    In the case of 50 ppm cadmium intake, the mortality was increased significantly beginning with the 28th week of intake coinciding with rapid increase of cadmium in the kidney and liver. Histologically, tubular damage was observed in the kidney.

Zusammenfassung

Weibliche Wistarratten wurden im Langzeitversuch mit cadmiumhaltiger Diät gefüttert. Es interessierten Cadmiumgehalt der Organe und Mortalität.

Dabei ergaben sich folgende Resultate:

  1. 1.

    Die Cadmiumaufnahme (10 ppm oder 50 ppm) führte zu einer sofortigen Reduzierung der Nahrungsaufnahme und des Wachstums. Nach 41 Wochen unterschied sich die Geschwindigkeit der Cadmiumanreicherung in Niere und Leber in der Gruppe mit 10 ppm (0.47%) nicht von der Gruppe mit 50 ppm (0.53%). Die vom Organ aufgenommene Gesamtmenge war jedoch von der Cadmiumkonzentration abhängig. Bei 10 ppm enthielten Niere und Leber die gleiche Menge an Cadmium, wohingegen bei 50 ppm die Niere nur ein Viertel der von der Leber aufgenommenen Cadmiummenge enthielt.

  2. 2.

    Bei 50 ppm Cadmium war die Mortalität von der 28. Woche an signifikant erhöht, wobei eine gleichzeitige schnelle Zunahme von Cadmium in Niere und Leber auftrat. Histologisch konnte eine Zerstörung der Nierentubuli beobachtet werden.

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Authors and Affiliations

  1. Department of Public Health, Sapporo Medical College, Sapporo, Japan

    N. Sugawara & C. Sugawara

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  1. N. Sugawara
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  2. C. Sugawara
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Sugawara, N., Sugawara, C. Cadmium accumulation in organs and mortality during a continued oral uptake. Arch. Toxicol. 32, 297–306 (1974). https://doi.org/10.1007/BF00330111

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  • DOI: https://doi.org/10.1007/BF00330111

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